Modafinil as an adjunctive treatment to sleep deprivation in depression

Sleep deprivation (SD) is a rapid-acting treatment for depression, but its clinical efficacy is hampered by high relapse rates after recovery sleep, and its effectiveness is reduced by the demanding effort needed for the patient to stay awake. To our knowledge, this is the first reported case of a s...

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Bibliographic Details
Published in:Journal of psychiatry & neuroscience 2005-11, Vol.30 (6), p.432-433
Main Authors: EVEN, Christian, THUILE, Jacques, SANTOS, Johana, BOURGIN, Patrice
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Aged
Benzhydryl Compounds - therapeutic use
Biological and medical sciences
Bipolar Disorder - complications
Brief Report
Central Nervous System Stimulants - therapeutic use
Depression
Depression, Mental
Depressive Disorder - complications
Depressive Disorder - psychology
Drug therapy
Evaluation
Fundamental and applied biological sciences. Psychology
Humans
Male
Medical sciences
Medical treatment
Mental depression
Modafinil
Mood disorders
Physiological aspects
Psychiatric Status Rating Scales
Psychoanalysis
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Psychopathology. Psychiatry
Sleep Deprivation
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Summary:Sleep deprivation (SD) is a rapid-acting treatment for depression, but its clinical efficacy is hampered by high relapse rates after recovery sleep, and its effectiveness is reduced by the demanding effort needed for the patient to stay awake. To our knowledge, this is the first reported case of a successful treatment of depression with the combination of SD and the wakefulness-promoting agent modafinil. We suggest that modafinil may reinforce the action of SD, possibly by preventing daytime naps and microsleep, and may sustain the antidepressant effect of SD, possibly by stabilizing the resynchronization between the circadian clock and the sleep-wake cycle.
ISSN:1180-4882
1488-2434