Protective Role of Faecal pH in Experimental Colon Carcinogenesis

There is epidemiological evidence that populations with alkaline stool pH are at greater risk for colon cancer than populations with acid stool pH. This association was investigated in the laboratory using the rat-dimethylhydrazine colon carcinogenesis model. Rats with acid stool pH, produced by con...

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Bibliographic Details
Published in:Journal of the Royal Society of Medicine 1985-03, Vol.78 (3), p.230-233
Main Authors: Samelson, Scott L, Nelson, Richard L, Nyhus, Lloyd M
Format: Article
Language:English
Subjects:
1,2-Dimethylhydrazine
Animals
Carcinogens
Colonic Neoplasms - etiology
Diet
Dimethylhydrazines
Feces
Hydrogen-Ion Concentration
Lactulose - administration & dosage
Male
Neoplasms, Experimental - etiology
Rats
Rats, Inbred Strains
Risk
Sulfates - administration & dosage
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Summary:There is epidemiological evidence that populations with alkaline stool pH are at greater risk for colon cancer than populations with acid stool pH. This association was investigated in the laboratory using the rat-dimethylhydrazine colon carcinogenesis model. Rats with acid stool pH, produced by consumption of lactulose or sodium sulphate or both, had significantly fewer colon tumours after injections of dimethylhydrazine (DMH) than rats treated with DMH alone. The results confirm the hypothesis that acidification of the stool can protect against the induction of colon cancer.
ISSN:0141-0768
1758-1095
DOI:10.1177/014107688507800311