The D2 dopamine receptor gene as a determinant of reward deficiency syndrome

The dopaminergic system, and in particular the dopamine D2 receptor, has been profoundly implicated in reward mechanisms in the brain. Dysfunction of the D2 dopamine receptors leads to aberrant substance seeking behaviour (alcohol, drug, tobacco, and food) and other related behaviours (pathological...

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Bibliographic Details
Published in:Journal of the Royal Society of Medicine 1996-07, Vol.89 (7), p.396-400
Main Authors: BLUM, K, SHERIDAN, P. J, WOOD, R. C, BRAVERMAN, E. R, CHEN, T. J. H, CULL, J. G, COMINGS, D. E
Format: Article
Language:English
Subjects:
Alcoholism and acute alcohol poisoning
Biological and medical sciences
Compulsive Behavior - genetics
Genetic Linkage
Humans
Medical sciences
Receptors, Dopamine D2 - genetics
Risk Factors
Substance-Related Disorders - genetics
Syndrome
Toxicology
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Summary:The dopaminergic system, and in particular the dopamine D2 receptor, has been profoundly implicated in reward mechanisms in the brain. Dysfunction of the D2 dopamine receptors leads to aberrant substance seeking behaviour (alcohol, drug, tobacco, and food) and other related behaviours (pathological gambling, Tourette's syndrome, and attention deficit hyperactivity disorder). We propose that variants of the D2 dopamine receptor gene are important common genetic determinants of the 'reward deficiency syndrome'.
ISSN:0141-0768
1758-1095
DOI:10.1177/014107689608900711