Platelets in inflammation and atherogenesis

Platelets represent an important linkage between inflammation, thrombosis, and atherogenesis. Inflammation is characterized by interactions among platelets, leukocytes, and ECs. These interactions trigger autocrine and paracrine activation processes that lead to leukocyte recruitment into the vascul...

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Bibliographic Details
Published in:The Journal of clinical investigation 2005-12, Vol.115 (12), p.3378-3384
Main Authors: Gawaz, Meinrad, Langer, Harald, May, Andreas E
Format: Article
Language:English
Subjects:
Adhesion
Adhesives
Animals
Arteriosclerosis - pathology
Atherosclerosis
Atherosclerosis - pathology
Biomedical research
Blood Platelets - metabolism
Blood Platelets - pathology
Blood Platelets - physiology
Cell Adhesion
Collagen
Disease Models, Animal
Endothelium
Glycoproteins
Hemostasis
Humans
Inflammation
Models, Biological
Monocytes - cytology
Platelet Adhesiveness
Proteins
Review Series
Selectins - metabolism
Thrombosis - pathology
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Summary:Platelets represent an important linkage between inflammation, thrombosis, and atherogenesis. Inflammation is characterized by interactions among platelets, leukocytes, and ECs. These interactions trigger autocrine and paracrine activation processes that lead to leukocyte recruitment into the vascular wall. Platelet-induced chronic inflammatory processes at the vascular wall result in development of atherosclerotic lesions and atherothrombosis. This Review highlights the molecular machinery and inflammatory pathways used by platelets to initiate and accelerate atherothrombosis.
ISSN:0021-9738
1558-8238
DOI:10.1172/JCI27196