Potent inhibitors of anthrax lethal factor from green tea

The anthrax lethal factor (LF) has a major role in the development of anthrax. LF is delivered by the protective antigen (PA) inside the cell, where it exerts its metalloprotease activity on the N‐terminus of MAPK‐kinases. PA+LF are cytotoxic to macrophages in culture and kill the Fischer 344 rat wh...

Full description

Saved in:
Bibliographic Details
Published in:EMBO reports 2004-04, Vol.5 (4), p.418-422
Main Authors: Dell'Aica, Isabella, Donà, Massimo, Tonello, Fiorella, Piris, Alejandro, Mock, Michèle, Montecucco, Cesare, Garbisa, Spiridione
Format: Article
Language:English
Subjects:
Animals
anthrax
Antigens, Bacterial
Apoptosis - drug effects
Bacterial Toxins - antagonists & inhibitors
Camellia sinensis - metabolism
Catechin - analogs & derivatives
Catechin - metabolism
Catechin - pharmacology
Green tea
green tea extract
inhibitor
Inhibitors
lethal toxin
Macrophages - drug effects
metalloprotease
Metalloproteases - antagonists & inhibitors
Mitogen-Activated Protein Kinase Kinases - metabolism
Rats
Rats, Inbred F344
Scientific Report
Tea - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The anthrax lethal factor (LF) has a major role in the development of anthrax. LF is delivered by the protective antigen (PA) inside the cell, where it exerts its metalloprotease activity on the N‐terminus of MAPK‐kinases. PA+LF are cytotoxic to macrophages in culture and kill the Fischer 344 rat when injected intravenously. We describe here the properties of some polyphenols contained in green tea as powerful inhibitors of LF metalloproteolytic activity, and how the main catechin of green tea, (−)epigallocatechin‐3‐gallate, prevents the LF‐induced death of macrophages and Fischer 344 rats.
ISSN:1469-221X
1469-3178
1469-221X
DOI:10.1038/sj.embor.7400118