crossveinless defines a new family of Twisted-gastrulation-like modulators of bone morphogenetic protein signalling

• Published in: EMBO reports 2005-03, Vol.6 (3), p.262-267
• Main Authors: Vilmos, Peter, Sousa-Neves, Rui, Lukacsovich, Tamas, Lawrence Marsh, J
• Format: Article
• Language: English
• Subjects: Alleles; Amino Acid Sequence; Animals; BMP; Bone Morphogenetic Proteins - genetics; Bone Morphogenetic Proteins - metabolism; crossvein; crossveinless; Diffusion; Drosophila; Drosophila melanogaster; Drosophila melanogaster - genetics; Drosophila melanogaster - growth & development; Drosophila melanogaster - metabolism; Drosophila Proteins - chemistry; Drosophila Proteins - classification; Drosophila Proteins - genetics; Drosophila Proteins - metabolism; Female; Gene Expression Regulation, Developmental; Genomics; Insects; Ligands; Male; Molecular Sequence Data; Proteins; Scientific Report; Sequence Alignment; Sequence Deletion - genetics; Signal Transduction; Substrate Specificity; twisted gastrulation; Vertebrates; Wings, Animal - growth & development; Wings, Animal - metabolism
• ISSN: 1469-221X; 1469-3178; 1469-221X
• DOI: 10.1038/sj.embor.7400347

The Twisted gastrulation (Tsg) proteins are modulators of bone morphogenetic protein (BMP) activity in both vertebrates and insects. We find that the crossveinless ( cv ) gene of Drosophila encodes a new tsg ‐like gene. Genetic experiments show that cv , similarly to tsg , interacts with short gastrulation ( sog ) to modulate BMP signalling. Despite this common property, Cv shows a different BMP ligand specificity as compared with Tsg, and its expression is limited to the developing wing. These findings and the presence of two types of Tsg‐like protein in several insects suggest that Cv represents a subgroup of the Tsg‐like BMP‐modulating proteins.