Evidence for a Novel Bursting Mechanism in Rodent Trigeminal Neurons

We investigated bursting behavior in rodent trigeminal neurons. The essential mechanisms operating in the biological systems were determined based on testable predictions of mathematical models. Bursting activity in trigeminal motoneurons is consistent with a traditional mechanism employing a region...

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Bibliographic Details
Published in:Biophysical journal 1998-07, Vol.75 (1), p.174-182
Main Authors: Del Negro, Christopher A., Hsiao, Chie-Fang, Chandler, Scott H., Garfinkel, Alan
Format: Article
Language:English
Subjects:
Action Potentials - physiology
Animals
Animals, Newborn
Biophysical Phenomena
Biophysics
Electrophysiology
In Vitro Techniques
Interneurons - physiology
Membrane Potentials - physiology
Models, Neurological
Motor Neurons - physiology
Rats
Trigeminal Nuclei - cytology
Trigeminal Nuclei - physiology
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Summary:We investigated bursting behavior in rodent trigeminal neurons. The essential mechanisms operating in the biological systems were determined based on testable predictions of mathematical models. Bursting activity in trigeminal motoneurons is consistent with a traditional mechanism employing a region of negative slope resistance in the steady-state current-voltage relationship (Smith, T. G. 1975. Nature. 253:450–452). However, the bursting dynamics of trigeminal interneurons is inconsistent with the traditional mechanisms, and is far more effectively explained by a new model of bursting that exploits the unique stability properties associated with spike threshold (Baer, S. M., T. Erneux, and J. Rinzel. 1989. SIAM J. Appl. Math. 49:55–71).
ISSN:0006-3495
1542-0086
DOI:10.1016/S0006-3495(98)77504-6