X-Ray Absorption Fine-Structure Spectroscopy Studies of Fe Sites in Natural Human Neuromelanin and Synthetic Analogues

X-ray absorption fine-structure spectroscopy is used to study the local environment of the iron site in natural (human) neuromelanin extracted from substantia nigra tissue and in various synthetic neuromelanins. All the materials show Fe centered in a nearest neighbor sixfold (distorted) oxygen octa...

Full description

Saved in:
Bibliographic Details
Published in:Biophysical journal 1998-12, Vol.75 (6), p.3135-3142
Main Authors: Kropf, A.J., Bunker, B.A., Eisner, M., Moss, S.C., Zecca, L., Stroppolo, A., Crippa, P.R.
Format: Article
Language:English
Subjects:
Biophysical Phenomena
Biophysics
Carbon - chemistry
Fourier Analysis
Humans
In Vitro Techniques
Iron - chemistry
Melanins - chemical synthesis
Melanins - chemistry
Oxygen - chemistry
Spectrum Analysis
Substantia Nigra - chemistry
X-Rays
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:X-ray absorption fine-structure spectroscopy is used to study the local environment of the iron site in natural (human) neuromelanin extracted from substantia nigra tissue and in various synthetic neuromelanins. All the materials show Fe centered in a nearest neighbor sixfold (distorted) oxygen octahedron; the Fe-O distances, while slightly different in the natural and synthetic neuromelanin, are both ∼2.0 Å. Appreciable differences arise, however, in the second (and higher) coordination shells. In this case the synthetic melanin has the four planar oxygens bound to carbon rings with Fe-C distances of ∼2.82 and 4.13 Å; the human sample does not show the 2.82 Å link but instead indicates a double shell at approximately 3.45 and 3.78 Å.
ISSN:0006-3495
1542-0086
DOI:10.1016/S0006-3495(98)77755-0