A Possible Resolution of the Gating Paradox

We introduce a Markov model for the gating of membrane channels. The model features a possible solution to the so-called gating current paradox, namely that the bell-shaped curve that describes the voltage dependence of the kinetics is broader than expected from, and shifted relative to, the sigmoid...

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Bibliographic Details
Published in:Biophysical journal 1999-04, Vol.76 (4), p.1918-1921
Main Authors: Endresen, L.P., Høye, J.S.
Format: Article
Language:English
Subjects:
Animals
Biophysical Phenomena
Biophysics
Ion Channel Gating - physiology
Kinetics
Markov Chains
Membrane Potentials
Membranes
Models, Biological
Thermodynamics
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Summary:We introduce a Markov model for the gating of membrane channels. The model features a possible solution to the so-called gating current paradox, namely that the bell-shaped curve that describes the voltage dependence of the kinetics is broader than expected from, and shifted relative to, the sigmoidal curve that describes the voltage dependence of the activation. The model also predicts some temperature dependence of this shift, but presence of the latter has not been tested experimentally so far.
ISSN:0006-3495
1542-0086
DOI:10.1016/S0006-3495(99)77350-9