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Osmotic Shock and the Strength of Viral Capsids
Osmotic shock is a familiar means for rupturing viral capsids and exposing their genomes intact. The necessary conditions for providing this shock involve incubation in high-concentration salt solutions, and lower permeability of the capsids to salt ions than to water molecules. We discuss here how...
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| Published in: | Biophysical journal 2003-07, Vol.85 (1), p.70-74 |
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| Main Authors: | , , , |
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| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c587t-bc4ba0b677e9c3bd270740691cb832a30f8810a1e5c96a23472c62136d4912ae3 |
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| container_title | Biophysical journal |
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| creator | Cordova, Amado Deserno, Markus Gelbart, William M. Ben-Shaul, Avinoam |
| description | Osmotic shock is a familiar means for rupturing viral capsids and exposing their genomes intact. The necessary conditions for providing this shock involve incubation in high-concentration salt solutions, and lower permeability of the capsids to salt ions than to water molecules. We discuss here how values of the capsid strength can be inferred from calculations of the osmotic pressure differences associated with measured values of the critical concentration of incubation solution. |
| doi_str_mv | 10.1016/S0006-3495(03)74455-5 |
| format | article |
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| ispartof | Biophysical journal, 2003-07, Vol.85 (1), p.70-74 |
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| language | eng |
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| source | Open Access: PubMed Central |
| subjects | Biophysical Theory and Modeling Capsid - chemistry Cellular biology Computer Simulation Deoxyribonucleic acid DNA Elasticity Electrolytes - chemistry Ions Models, Chemical Models, Molecular Molecular Conformation Osmosis Osmotic Pressure Permeability Porosity Pressure Proteins Salts - chemistry Solutions - chemistry Stress, Mechanical Viruses - chemistry Water - chemistry |
| title | Osmotic Shock and the Strength of Viral Capsids |
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