Polyamines in Clinical Disorders

An edited summary of an Interdepartmental Conference arranged by the Department of Medicine of the UCLA School of Medicine, Los Angeles. The Director of Conferences is William M. Pardridge, MD, Associate Professor of Medicine. Polyamines, necessary for cell growth, influence many cell functions. As...

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Bibliographic Details
Published in:The Western journal of medicine 1985-01, Vol.142 (1), p.63-73
Main Authors: Tierney, Donald F., Marton, Laurence J., Hacker, Allen D., Lowe, Nicholas
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - therapeutic use
Cell Division
DNA - metabolism
DNA, Neoplasm - metabolism
Humans
Lung - metabolism
Neoplasms - drug therapy
Neoplasms - metabolism
Oxygen - poisoning
Polyamines - metabolism
Polyamines - pharmacology
Psoriasis - drug therapy
Psoriasis - metabolism
Retinoids - therapeutic use
Skin - metabolism
Specialty Conference
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Summary:An edited summary of an Interdepartmental Conference arranged by the Department of Medicine of the UCLA School of Medicine, Los Angeles. The Director of Conferences is William M. Pardridge, MD, Associate Professor of Medicine. Polyamines, necessary for cell growth, influence many cell functions. As small polyvalent cations they can change the configuration of large polyvalent anions, such as DNA, and alter their sensitivity to other molecules including chemotherapeutic agents. By altering polyamine content in a cell, we can change its growth, its susceptibility to drugs and change other cellular functions. Malignant conditions, other proliferative diseases and infections are the most apparent clinical conditions likely to improve by depleting polyamines and suppressing cell growth. Proliferative disorders of the skin respond to many agents that suppress polyamine metabolism. Hyperoxia may suppress cell growth in the lung by suppressing polyamine metabolism.
ISSN:0093-0415
1476-2978