Configurational entropy of native proteins

Simulations of the residual configurational entropy of a protein in the native state suggest that it is nearly an order of magnitude larger than the entropy of denaturation. The implications of this result are discussed.

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Bibliographic Details
Published in:Biophysical journal 1987-12, Vol.52 (6), p.1083-1085
Main Authors: Karplus, M., Ichiye, T., Pettitt, B.M.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Mathematics
Molecular biophysics
Protein Conformation
Proteins
Structure in molecular biology
Thermodynamics
Tridimensional structure
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Description
Summary:Simulations of the residual configurational entropy of a protein in the native state suggest that it is nearly an order of magnitude larger than the entropy of denaturation. The implications of this result are discussed.
ISSN:0006-3495
1542-0086
DOI:10.1016/S0006-3495(87)83303-9