Mass action kinetics of virus-cell aggregation and fusion

A simple approximate solution for the mass action kinetics of small particles (viruses or vesicles) binding to large particles (cells) and their subsequent fusion has been derived. The solution is evaluated in terms of the measurable fluorescence changes expected when the virus or vesicles are label...

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Bibliographic Details
Published in:Biophysical journal 1988-09, Vol.54 (3), p.449-462
Main Authors: Bentz, J., Nir, S., Covell, D.G.
Format: Article
Language:English
Subjects:
Biological and medical sciences
cell fusion
Cell Membrane - physiology
Cell Physiological Phenomena
fluorescence
Fundamental and applied biological sciences. Psychology
General aspects, investigation technics, apparatus
Kinetics
Mathematics
Models, Theoretical
Spectrometry, Fluorescence - methods
Tissues, organs and organisms biophysics
Virus Physiological Phenomena
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Summary:A simple approximate solution for the mass action kinetics of small particles (viruses or vesicles) binding to large particles (cells) and their subsequent fusion has been derived. The solution is evaluated in terms of the measurable fluorescence changes expected when the virus or vesicles are labeled with fluorescent probes, which are diluted into the cellular membrane by fusion. Comparison with numerical integrations shows that the approximate solution is extremely accurate. Analytic simplifications for a variety of special cases of this general problem are also shown.
ISSN:0006-3495
1542-0086
DOI:10.1016/S0006-3495(88)82978-3