Loading…

Mass action kinetics of virus-cell aggregation and fusion

A simple approximate solution for the mass action kinetics of small particles (viruses or vesicles) binding to large particles (cells) and their subsequent fusion has been derived. The solution is evaluated in terms of the measurable fluorescence changes expected when the virus or vesicles are label...

Full description

Saved in:

Bibliographic Details
Published in:	Biophysical journal 1988-09, Vol.54 (3), p.449-462
Main Authors:	Bentz, J., Nir, S., Covell, D.G.
Format:	Article
Language:	English
Subjects:	Biological and medical sciences cell fusion Cell Membrane - physiology Cell Physiological Phenomena fluorescence Fundamental and applied biological sciences. Psychology General aspects, investigation technics, apparatus Kinetics Mathematics Models, Theoretical Spectrometry, Fluorescence - methods Tissues, organs and organisms biophysics Virus Physiological Phenomena
Citations:	Items that cite this one
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

cited_by	cdi_FETCH-LOGICAL-c522t-2553feac6cdfca725c2c337cb7ff5f51511ef67ed50a8684ce2438f63378b48d3
cites
container_end_page	462
container_issue	3
container_start_page	449
container_title	Biophysical journal
container_volume	54
creator	Bentz, J. Nir, S. Covell, D.G.
description	A simple approximate solution for the mass action kinetics of small particles (viruses or vesicles) binding to large particles (cells) and their subsequent fusion has been derived. The solution is evaluated in terms of the measurable fluorescence changes expected when the virus or vesicles are labeled with fluorescent probes, which are diluted into the cellular membrane by fusion. Comparison with numerical integrations shows that the approximate solution is extremely accurate. Analytic simplifications for a variety of special cases of this general problem are also shown.
doi_str_mv	10.1016/S0006-3495(88)82978-3
format	article
fullrecord	<record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1330344</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0006349588829783</els_id><sourcerecordid>15141068</sourcerecordid><originalsourceid>FETCH-LOGICAL-c522t-2553feac6cdfca725c2c337cb7ff5f51511ef67ed50a8684ce2438f63378b48d3</originalsourceid><addsrcrecordid>eNqFkU1P3DAQhi0Egi3wE5ByqFB7CPVH_JFLqwq1UImqB-BseSfjYMgm1E5W6r9vNhtF7YmTR5pnXr8zLyEXjF4xytSne0qpykVRyg_GfDS81CYXB2TFZMFzSo06JKsFOSHvUnqmlHFJ2TE5FpxqI8SKlD9dSpmDPnRt9hJa7AOkrPPZNsQh5YBNk7m6jli7CXFtlfkhjeUZOfKuSXg-v6fk8fu3h-vb_O7XzY_rr3c5SM77nEspPDpQUHlwmkvgIISGtfZeeskkY-iVxkpSZ5QpAHkhjFcjY9aFqcQp-bzXfR3WG6wA2z66xr7GsHHxj-1csP932vBk625rmRBUFMUocDkLxO73gKm3m5B2i7kWuyFZbWRpSibfBEevBaPKjKDcgxC7lCL6xQ2jdheOncKxu8tbY-wUjhXj3MW_qyxTcxpj__3cdwlc46NrIaQFU7qkevr-yx7D8ezbgNEmCNgCViEi9LbqwhtG_gIHbawd</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>15141068</pqid></control><display><type>article</type><title>Mass action kinetics of virus-cell aggregation and fusion</title><source>PubMed Central</source><creator>Bentz, J. ; Nir, S. ; Covell, D.G.</creator><creatorcontrib>Bentz, J. ; Nir, S. ; Covell, D.G.</creatorcontrib><description>A simple approximate solution for the mass action kinetics of small particles (viruses or vesicles) binding to large particles (cells) and their subsequent fusion has been derived. The solution is evaluated in terms of the measurable fluorescence changes expected when the virus or vesicles are labeled with fluorescent probes, which are diluted into the cellular membrane by fusion. Comparison with numerical integrations shows that the approximate solution is extremely accurate. Analytic simplifications for a variety of special cases of this general problem are also shown.</description><identifier>ISSN: 0006-3495</identifier><identifier>EISSN: 1542-0086</identifier><identifier>DOI: 10.1016/S0006-3495(88)82978-3</identifier><identifier>PMID: 3207833</identifier><identifier>CODEN: BIOJAU</identifier><language>eng</language><publisher>Bethesda, MD: Elsevier Inc</publisher><subject>Biological and medical sciences ; cell fusion ; Cell Membrane - physiology ; Cell Physiological Phenomena ; fluorescence ; Fundamental and applied biological sciences. Psychology ; General aspects, investigation technics, apparatus ; Kinetics ; Mathematics ; Models, Theoretical ; Spectrometry, Fluorescence - methods ; Tissues, organs and organisms biophysics ; Virus Physiological Phenomena</subject><ispartof>Biophysical journal, 1988-09, Vol.54 (3), p.449-462</ispartof><rights>1988 The Biophysical Society</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-2553feac6cdfca725c2c337cb7ff5f51511ef67ed50a8684ce2438f63378b48d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1330344/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1330344/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6790768$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3207833$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bentz, J.</creatorcontrib><creatorcontrib>Nir, S.</creatorcontrib><creatorcontrib>Covell, D.G.</creatorcontrib><title>Mass action kinetics of virus-cell aggregation and fusion</title><title>Biophysical journal</title><addtitle>Biophys J</addtitle><description>A simple approximate solution for the mass action kinetics of small particles (viruses or vesicles) binding to large particles (cells) and their subsequent fusion has been derived. The solution is evaluated in terms of the measurable fluorescence changes expected when the virus or vesicles are labeled with fluorescent probes, which are diluted into the cellular membrane by fusion. Comparison with numerical integrations shows that the approximate solution is extremely accurate. Analytic simplifications for a variety of special cases of this general problem are also shown.</description><subject>Biological and medical sciences</subject><subject>cell fusion</subject><subject>Cell Membrane - physiology</subject><subject>Cell Physiological Phenomena</subject><subject>fluorescence</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects, investigation technics, apparatus</subject><subject>Kinetics</subject><subject>Mathematics</subject><subject>Models, Theoretical</subject><subject>Spectrometry, Fluorescence - methods</subject><subject>Tissues, organs and organisms biophysics</subject><subject>Virus Physiological Phenomena</subject><issn>0006-3495</issn><issn>1542-0086</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><recordid>eNqFkU1P3DAQhi0Egi3wE5ByqFB7CPVH_JFLqwq1UImqB-BseSfjYMgm1E5W6r9vNhtF7YmTR5pnXr8zLyEXjF4xytSne0qpykVRyg_GfDS81CYXB2TFZMFzSo06JKsFOSHvUnqmlHFJ2TE5FpxqI8SKlD9dSpmDPnRt9hJa7AOkrPPZNsQh5YBNk7m6jli7CXFtlfkhjeUZOfKuSXg-v6fk8fu3h-vb_O7XzY_rr3c5SM77nEspPDpQUHlwmkvgIISGtfZeeskkY-iVxkpSZ5QpAHkhjFcjY9aFqcQp-bzXfR3WG6wA2z66xr7GsHHxj-1csP932vBk625rmRBUFMUocDkLxO73gKm3m5B2i7kWuyFZbWRpSibfBEevBaPKjKDcgxC7lCL6xQ2jdheOncKxu8tbY-wUjhXj3MW_qyxTcxpj__3cdwlc46NrIaQFU7qkevr-yx7D8ezbgNEmCNgCViEi9LbqwhtG_gIHbawd</recordid><startdate>19880901</startdate><enddate>19880901</enddate><creator>Bentz, J.</creator><creator>Nir, S.</creator><creator>Covell, D.G.</creator><general>Elsevier Inc</general><general>Biophysical Society</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19880901</creationdate><title>Mass action kinetics of virus-cell aggregation and fusion</title><author>Bentz, J. ; Nir, S. ; Covell, D.G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c522t-2553feac6cdfca725c2c337cb7ff5f51511ef67ed50a8684ce2438f63378b48d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Biological and medical sciences</topic><topic>cell fusion</topic><topic>Cell Membrane - physiology</topic><topic>Cell Physiological Phenomena</topic><topic>fluorescence</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects, investigation technics, apparatus</topic><topic>Kinetics</topic><topic>Mathematics</topic><topic>Models, Theoretical</topic><topic>Spectrometry, Fluorescence - methods</topic><topic>Tissues, organs and organisms biophysics</topic><topic>Virus Physiological Phenomena</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bentz, J.</creatorcontrib><creatorcontrib>Nir, S.</creatorcontrib><creatorcontrib>Covell, D.G.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biophysical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bentz, J.</au><au>Nir, S.</au><au>Covell, D.G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mass action kinetics of virus-cell aggregation and fusion</atitle><jtitle>Biophysical journal</jtitle><addtitle>Biophys J</addtitle><date>1988-09-01</date><risdate>1988</risdate><volume>54</volume><issue>3</issue><spage>449</spage><epage>462</epage><pages>449-462</pages><issn>0006-3495</issn><eissn>1542-0086</eissn><coden>BIOJAU</coden><abstract>A simple approximate solution for the mass action kinetics of small particles (viruses or vesicles) binding to large particles (cells) and their subsequent fusion has been derived. The solution is evaluated in terms of the measurable fluorescence changes expected when the virus or vesicles are labeled with fluorescent probes, which are diluted into the cellular membrane by fusion. Comparison with numerical integrations shows that the approximate solution is extremely accurate. Analytic simplifications for a variety of special cases of this general problem are also shown.</abstract><cop>Bethesda, MD</cop><pub>Elsevier Inc</pub><pmid>3207833</pmid><doi>10.1016/S0006-3495(88)82978-3</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record>
fulltext	fulltext
identifier	ISSN: 0006-3495
ispartof	Biophysical journal, 1988-09, Vol.54 (3), p.449-462
issn	0006-3495 1542-0086
language	eng
recordid	cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1330344
source	PubMed Central
subjects	Biological and medical sciences cell fusion Cell Membrane - physiology Cell Physiological Phenomena fluorescence Fundamental and applied biological sciences. Psychology General aspects, investigation technics, apparatus Kinetics Mathematics Models, Theoretical Spectrometry, Fluorescence - methods Tissues, organs and organisms biophysics Virus Physiological Phenomena
title	Mass action kinetics of virus-cell aggregation and fusion
url	http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T20%3A23%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Mass%20action%20kinetics%20of%20virus-cell%20aggregation%20and%20fusion&rft.jtitle=Biophysical%20journal&rft.au=Bentz,%20J.&rft.date=1988-09-01&rft.volume=54&rft.issue=3&rft.spage=449&rft.epage=462&rft.pages=449-462&rft.issn=0006-3495&rft.eissn=1542-0086&rft.coden=BIOJAU&rft_id=info:doi/10.1016/S0006-3495(88)82978-3&rft_dat=%3Cproquest_pubme%3E15141068%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c522t-2553feac6cdfca725c2c337cb7ff5f51511ef67ed50a8684ce2438f63378b48d3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=15141068&rft_id=info:pmid/3207833&rfr_iscdi=true