The mechanism of thyroxine transfer from plasma to tissue binding sites

1. An examination has been made of the uptake of thyroxine by rat livers perfused with very dilute solutions of thyroxine-binding globulin (TBG) and thyroxine-binding pre-albumin (TBPA). 2. Under these circumstances the rate of transfer of thyroxine to the liver is very similar to the rate of thyrox...

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Bibliographic Details
Published in:The Journal of physiology 1971-09, Vol.217 (3), p.635-639
Main Author: Hillier, A. P.
Format: Article
Language:English
Subjects:
Animals
Binding Sites
In Vitro Techniques
Liver - metabolism
Perfusion
Protein Binding
Rats
Serum Albumin - metabolism
Serum Globulins - metabolism
Thyroxine - metabolism
Thyroxine-Binding Proteins - metabolism
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Summary:1. An examination has been made of the uptake of thyroxine by rat livers perfused with very dilute solutions of thyroxine-binding globulin (TBG) and thyroxine-binding pre-albumin (TBPA). 2. Under these circumstances the rate of transfer of thyroxine to the liver is very similar to the rate of thyroxine dissociation for both TBG and TBPA. 3. It is concluded that thyroxine transfer from plasma to tissue-binding sites involves its initial release into the free state and not, as has been suggested, directed exchange.
ISSN:0022-3751
1469-7793
DOI:10.1113/jphysiol.1971.sp009590