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The mechanism of thyroxine transfer from plasma to tissue binding sites
1. An examination has been made of the uptake of thyroxine by rat livers perfused with very dilute solutions of thyroxine-binding globulin (TBG) and thyroxine-binding pre-albumin (TBPA). 2. Under these circumstances the rate of transfer of thyroxine to the liver is very similar to the rate of thyrox...
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| Published in: | The Journal of physiology 1971-09, Vol.217 (3), p.635-639 |
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| Main Author: | |
| Format: | Article |
| Language: | English |
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| container_end_page | 639 |
| container_issue | 3 |
| container_start_page | 635 |
| container_title | The Journal of physiology |
| container_volume | 217 |
| creator | Hillier, A. P. |
| description | 1. An examination has been made of the uptake of thyroxine by rat livers perfused with very dilute solutions of thyroxine-binding
globulin (TBG) and thyroxine-binding pre-albumin (TBPA).
2. Under these circumstances the rate of transfer of thyroxine to the liver is very similar to the rate of thyroxine dissociation
for both TBG and TBPA.
3. It is concluded that thyroxine transfer from plasma to tissue-binding sites involves its initial release into the free
state and not, as has been suggested, directed exchange. |
| doi_str_mv | 10.1113/jphysiol.1971.sp009590 |
| format | article |
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globulin (TBG) and thyroxine-binding pre-albumin (TBPA).
2. Under these circumstances the rate of transfer of thyroxine to the liver is very similar to the rate of thyroxine dissociation
for both TBG and TBPA.
3. It is concluded that thyroxine transfer from plasma to tissue-binding sites involves its initial release into the free
state and not, as has been suggested, directed exchange.</description><identifier>ISSN: 0022-3751</identifier><identifier>EISSN: 1469-7793</identifier><identifier>DOI: 10.1113/jphysiol.1971.sp009590</identifier><identifier>PMID: 4999674</identifier><language>eng</language><publisher>England: The Physiological Society</publisher><subject>Animals ; Binding Sites ; In Vitro Techniques ; Liver - metabolism ; Perfusion ; Protein Binding ; Rats ; Serum Albumin - metabolism ; Serum Globulins - metabolism ; Thyroxine - metabolism ; Thyroxine-Binding Proteins - metabolism</subject><ispartof>The Journal of physiology, 1971-09, Vol.217 (3), p.635-639</ispartof><rights>1971 The Physiological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5005-4ebbbedeac485cd3840416db48ee9359bfd38fa2c1e6868536c556d81d58a12f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1331567/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1331567/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4999674$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hillier, A. P.</creatorcontrib><title>The mechanism of thyroxine transfer from plasma to tissue binding sites</title><title>The Journal of physiology</title><addtitle>J Physiol</addtitle><description>1. An examination has been made of the uptake of thyroxine by rat livers perfused with very dilute solutions of thyroxine-binding
globulin (TBG) and thyroxine-binding pre-albumin (TBPA).
2. Under these circumstances the rate of transfer of thyroxine to the liver is very similar to the rate of thyroxine dissociation
for both TBG and TBPA.
3. It is concluded that thyroxine transfer from plasma to tissue-binding sites involves its initial release into the free
state and not, as has been suggested, directed exchange.</description><subject>Animals</subject><subject>Binding Sites</subject><subject>In Vitro Techniques</subject><subject>Liver - metabolism</subject><subject>Perfusion</subject><subject>Protein Binding</subject><subject>Rats</subject><subject>Serum Albumin - metabolism</subject><subject>Serum Globulins - metabolism</subject><subject>Thyroxine - metabolism</subject><subject>Thyroxine-Binding Proteins - metabolism</subject><issn>0022-3751</issn><issn>1469-7793</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1971</creationdate><recordtype>article</recordtype><recordid>eNqNkUFv1DAQhS1EVZbCTwD5RE_ZeuLYsS9IUEEBVYLDcrYcZ7JxlcTBztLm35NVthXcOFma997n0TxC3gLbAgC_uhvbOfnQbUGXsE0jY1po9oxsoJA6K0vNn5MNY3me8VLAC_IypTvGgDOtz8l5obWWZbEhN7sWaY-utYNPPQ0Nndo5hgc_IJ2iHVKDkTYx9HTsbOotnQKdfEoHpJUfaj_safITplfkrLFdwten94L8_Pxpd_0lu_1-8_X6w23mBGMiK7CqKqzRukIJV3NVsAJkXRUKUXOhq2aZNTZ3gFJJJbh0QshaQS2UhbzhF-T9yh0PVY-1w2HZsjNj9L2NswnWm3-VwbdmH34b4ByELBfAuxMghl8HTJPpfXLYdXbAcEhGAeSFVLAY5Wp0MaQUsXn6BJg5VmAeKzDHCsxjBUvwzd8rPsVON1_0j6t-7zuc_5Nqdt9-HAc5lFxysUAuV0jr9-29j2jWWArO4zSbxWe4OTr_AHPUqpY</recordid><startdate>19710901</startdate><enddate>19710901</enddate><creator>Hillier, A. P.</creator><general>The Physiological Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19710901</creationdate><title>The mechanism of thyroxine transfer from plasma to tissue binding sites</title><author>Hillier, A. P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5005-4ebbbedeac485cd3840416db48ee9359bfd38fa2c1e6868536c556d81d58a12f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1971</creationdate><topic>Animals</topic><topic>Binding Sites</topic><topic>In Vitro Techniques</topic><topic>Liver - metabolism</topic><topic>Perfusion</topic><topic>Protein Binding</topic><topic>Rats</topic><topic>Serum Albumin - metabolism</topic><topic>Serum Globulins - metabolism</topic><topic>Thyroxine - metabolism</topic><topic>Thyroxine-Binding Proteins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hillier, A. P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hillier, A. P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The mechanism of thyroxine transfer from plasma to tissue binding sites</atitle><jtitle>The Journal of physiology</jtitle><addtitle>J Physiol</addtitle><date>1971-09-01</date><risdate>1971</risdate><volume>217</volume><issue>3</issue><spage>635</spage><epage>639</epage><pages>635-639</pages><issn>0022-3751</issn><eissn>1469-7793</eissn><abstract>1. An examination has been made of the uptake of thyroxine by rat livers perfused with very dilute solutions of thyroxine-binding
globulin (TBG) and thyroxine-binding pre-albumin (TBPA).
2. Under these circumstances the rate of transfer of thyroxine to the liver is very similar to the rate of thyroxine dissociation
for both TBG and TBPA.
3. It is concluded that thyroxine transfer from plasma to tissue-binding sites involves its initial release into the free
state and not, as has been suggested, directed exchange.</abstract><cop>England</cop><pub>The Physiological Society</pub><pmid>4999674</pmid><doi>10.1113/jphysiol.1971.sp009590</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3751 |
| ispartof | The Journal of physiology, 1971-09, Vol.217 (3), p.635-639 |
| issn | 0022-3751 1469-7793 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1331567 |
| source | PubMed Central (Open Access) |
| subjects | Animals Binding Sites In Vitro Techniques Liver - metabolism Perfusion Protein Binding Rats Serum Albumin - metabolism Serum Globulins - metabolism Thyroxine - metabolism Thyroxine-Binding Proteins - metabolism |
| title | The mechanism of thyroxine transfer from plasma to tissue binding sites |
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