Prevalence of antibody to poliovirus in England and Wales 1984-6

Serum from 995 subjects aged 6 months to 99 years was screened at a dilution of 1/8 for neutralising antibodies to poliovirus. Of these samples, 975 (98%) contained antibody to at least one serotype, and 763 (77%) contained antibody to all three, an improvement since previous studies. Children aged...

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Bibliographic Details
Published in:BMJ 1986-11, Vol.293 (6555), p.1153-1155
Main Authors: White, P M, Green, J
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Antibodies
Antibodies, Viral - immunology
Child
Child, Preschool
Children
Contemporary Themes
Dosage
England
Humans
Immunity
Infant
Middle Aged
Polio
Poliomyelitis
Poliomyelitis - immunology
Poliomyelitis - prevention & control
Poliovirus
Poliovirus - immunology
Poliovirus Vaccine, Oral - immunology
Public health
Vaccination
Viruses
Wales
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Summary:Serum from 995 subjects aged 6 months to 99 years was screened at a dilution of 1/8 for neutralising antibodies to poliovirus. Of these samples, 975 (98%) contained antibody to at least one serotype, and 763 (77%) contained antibody to all three, an improvement since previous studies. Children aged 8 to 15, however, had a low prevalence of antibody to poliovirus type 3, with only four (40%) of those aged 12 protected. This finding is possibly due to the waning of antibodies induced by the type 3 component of oral poliovirus vaccine and emphasises the continued importance of a booster dose of vaccine for those leaving school.
ISSN:0267-0623
0959-8138
1468-5833
DOI:10.1136/bmj.293.6555.1153