Hyaluronidase (Hyalase): a useful addition in haematoma block?

OBJECTIVE: To investigate whether hyaluronidase (Hyalase) is a useful and justified addition to haematoma block for pain relief. METHODS: The study was a randomised double blind trial of 33 consecutive patients attending the accident and emergency department for manipulation of distal radius fractur...

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Bibliographic Details
Published in:Emergency medicine journal : EMJ 1996-09, Vol.13 (5), p.337-338
Main Authors: London, N J, Osman, F A, Ramagopal, K, Journeaux, S F
Format: Article
Language:English
Subjects:
Anesthetics, Local
Double-Blind Method
Drug Combinations
Humans
Hyaluronoglucosaminidase
Lidocaine
Manipulation, Orthopedic - adverse effects
Nerve Block - methods
Pain - drug therapy
Pain - etiology
Pain Measurement
Patient Satisfaction
Radius Fractures - therapy
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Summary:OBJECTIVE: To investigate whether hyaluronidase (Hyalase) is a useful and justified addition to haematoma block for pain relief. METHODS: The study was a randomised double blind trial of 33 consecutive patients attending the accident and emergency department for manipulation of distal radius fracture under haematoma block. Control patients received 1% lignocaine; the treatment group received 1% lignocaine plus 1500 IU hyaluronidase. Manipulation occurred 10 minutes after instituting the block. RESULTS: 16 patients received hyaluronidase, 17 received lignocaine only. One patient with unsuccessful manipulation was excluded. There was no significant difference between the two groups for any of three methods of pain assessment (P > 0.05, Mann Whitney). CONCLUSIONS: The addition of hyaluronidase does not increase the efficacy of the haematoma block when 10 minutes are allowed to elapse before manipulation, and the increased cost of adding (and risk of allergy) is not justified by any theoretical increased speed of analgesia.
ISSN:1351-0622
1472-0205
1472-0213
DOI:10.1136/emj.13.5.337