Erythrocyte 2,3-diphosphoglycerate in endotoxic shock in the subhuman primate: response to fluid and-or methylprednisolone succinate

The effects of shock as a result of Escherichia coli endotoxin on certain hemodynamic and biochemical parameters and mortality were studied in the baboon. The ability of methylprednisolone succinate (MPS) in massive doses and/or rapid infusion of a buffered electrolyte solution to influence the resu...

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Bibliographic Details
Published in:Annals of surgery 1974-11, Vol.180 (5), p.783-786
Main Authors: Johnson, Jr, G, McDevitt, N B, Proctor, H J
Format: Article
Language:English
Subjects:
Animals
Blood Pressure
Carbon Dioxide - blood
Cardiac Output
Diphosphoglyceric Acids - blood
Erythrocytes - metabolism
Escherichia coli
Hydrogen-Ion Concentration
Infusions, Parenteral
Lactates - blood
Methylprednisolone - pharmacology
Methylprednisolone - therapeutic use
Oxygen - blood
Papio
Shock, Septic - blood
Shock, Septic - drug therapy
Shock, Septic - mortality
Shock, Septic - therapy
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Summary:The effects of shock as a result of Escherichia coli endotoxin on certain hemodynamic and biochemical parameters and mortality were studied in the baboon. The ability of methylprednisolone succinate (MPS) in massive doses and/or rapid infusion of a buffered electrolyte solution to influence the results was then examined. Shock secondary to Escherichia coli endotoxin was associated with a decrease in RBC 2,3-DPG. This fall in RBC 2,3-DPG was not significantly influenced by MPS. Likewise, MPS did not prevent the changes in oxygen metabolism or systemic hemodynamics, nor was it associated with any decrease in mortality associated with endotoxic shock. Buffered electrolyte solution therapy improved both hemodynamics and mortality, but did not significantly protect against changes in RBC 2,3-DPG.
ISSN:0003-4932
1528-1140
DOI:10.1097/00000658-197411000-00013