Natural Human Antibody Responses to Plasmodium vivax Apical Membrane Antigen 1 under Low Transmission and Unstable Malaria Conditions in Sri Lanka

Plasmodium vivax apical membrane antigen 1, an important malaria vaccine candidate, was immunogenic during natural malaria infections in Sri Lanka, where low transmission and unstable malaria conditions prevail. Antibody prevalence increased with exposure in areas where malaria was or was not endemi...

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Bibliographic Details
Published in:Infection and Immunity 2006, Vol.74 (1), p.798-801
Main Authors: Wickramarachchi, Thilan, Premaratne, Prasad H, Perera, K. L. R. Lakshman, Bandara, Sumith, Kocken, Clemens H. M, Thomas, Alan W, Handunnetti, Shiroma M, Udagama-Randeniya, Preethi V
Format: Article
Language:English
Subjects:
Animals
Antibodies, Protozoan - biosynthesis
antibody formation
antigens
Antigens, Protozoan - immunology
Biological and medical sciences
cell membranes
disease transmission
Fundamental and applied biological sciences. Psychology
Human protozoal diseases
Humans
immunoglobulin G
Immunoglobulin G - biosynthesis
Infectious diseases
Malaria
Malaria, Vivax - epidemiology
Malaria, Vivax - immunology
Medical sciences
Membrane Proteins - immunology
Microbial Immunity and Vaccines
Microbiology
Parasitic diseases
Plasmodium vivax
Plasmodium vivax - immunology
Protozoal diseases
Protozoan Proteins - immunology
Sri Lanka - epidemiology
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Summary:Plasmodium vivax apical membrane antigen 1, an important malaria vaccine candidate, was immunogenic during natural malaria infections in Sri Lanka, where low transmission and unstable malaria conditions prevail. Antibody prevalence increased with exposure in areas where malaria was or was not endemic. A marked isotype switch to cytophilic (immunoglobulin G1 [IgG1]/IgG3) antibodies was evident with increasing exposure exclusively in residents from areas of endemicity.
ISSN:0019-9567
1098-5522
DOI:10.1128/IAI.74.1.798-801.2006