Effect of splenectomy on first cadaver kidney transplants

A prospective study was begun in January 1975 to evaluate the effect of splenectomy on graft and patient survival in recipients of first cadaver kidney transplants. Ninety-two cases were evaluated. Splenectomy increased the survival of both grafts and recipients. The benefit from splenectomy compens...

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Bibliographic Details
Published in:Annals of surgery 1980-01, Vol.192 (4), p.553-561
Main Authors: Stuart, F P, Reckard, C R, Ketel, B L, Schulak, J A
Format: Article
Language:English
Subjects:
Adult
African Continental Ancestry Group
Cadaver
European Continental Ancestry Group
Female
Graft Survival
Humans
Immunosuppression
Kidney Transplantation
Male
Splenectomy
Transplantation Immunology
Transplantation, Homologous
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Summary:A prospective study was begun in January 1975 to evaluate the effect of splenectomy on graft and patient survival in recipients of first cadaver kidney transplants. Ninety-two cases were evaluated. Splenectomy increased the survival of both grafts and recipients. The benefit from splenectomy compensated readily for the perioperative morbidity of splenectomy and the long-term increased risk of sepsis from certain bacteria for the asplenic patient. Splenectomy exerted its effect by reducing the incidence and intensity of rejection episodes. It was not clear whether the observation resulted from a direct immunosuppressive effect of splenectomy or from the increased tolerance to azathioprine observed in asplenic recipients. Finally, splenectomy negated an effect of race that had been observed earlier for survival of cadaver transplants and recipients.
ISSN:0003-4932
1528-1140
DOI:10.1097/00000658-198010000-00013