The effect of citric acid and its sodium salts in test meals on the gastric outputs of acid and of chloride

Five subjects were given 750 ml. test meals lasting 10-20 min, containing 0-300 m N citric acid, monosodium dihydrogen citrate, disodium monohydrogen citrate or trisodium citrate. 1. Increase in concentration of sodium citrate in the range 0-125 m N gave increasing outputs of acid and chloride. 2. T...

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Bibliographic Details
Published in:The Journal of physiology 1973-04, Vol.230 (1), p.171-184
Main Authors: Hunt, J. N., Knox, M. T.
Format: Article
Language:English
Subjects:
Chlorides - metabolism
Citrates - administration & dosage
Citrates - pharmacology
Diffusion
Gastric Juice - metabolism
Gastric Mucosa - drug effects
Gastric Mucosa - metabolism
Humans
Hydrogen-Ion Concentration
Male
Secretory Rate - drug effects
Sensory Receptor Cells
Sodium
Stomach - innervation
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Summary:Five subjects were given 750 ml. test meals lasting 10-20 min, containing 0-300 m N citric acid, monosodium dihydrogen citrate, disodium monohydrogen citrate or trisodium citrate. 1. Increase in concentration of sodium citrate in the range 0-125 m N gave increasing outputs of acid and chloride. 2. The more acid the meal for any given citrate ion concentration, the less the output of acid and chloride. 3. The greater the concentration of an acid citrate salt, the less the output of acid. 4. There was evidence of loss of acid from the stomach by diffusion with the more acid meals.
ISSN:0022-3751
1469-7793
DOI:10.1113/jphysiol.1973.sp010181