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effects of engorgement with milk and of suckling on mammary blood flow in the rat
1. Mammary blood flow was estimated in rats by measuring the cardiac output and the proportion of it received by the mammary glands. 2. When the young were removed on the 10th day of lactation the mammary glands began to fill with milk and mammary blood flow fell from 78 ml./min. 100 g tissue to 45...
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| Published in: | The Journal of physiology 1973-08, Vol.233 (1), p.111-125 |
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| Language: | English |
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| container_end_page | 125 |
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| container_start_page | 111 |
| container_title | The Journal of physiology |
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| creator | Hanwell, A Linzell, J.L |
| description | 1. Mammary blood flow was estimated in rats by measuring the cardiac output and the proportion of it received by the mammary
glands.
2. When the young were removed on the 10th day of lactation the mammary glands began to fill with milk and mammary blood flow
fell from 78 ml./min. 100 g tissue to 45 ml./min. 100 g within 8 hr and decreased further to 34 ml./min. 100 g within 8 hr
and decreased further to 34 ml./min. 100 g in the next 16 hr. These changes were associated with both a fall in cardiac output
and a fall in the proportion of the cardiac output taken by the mammary glands.
3. When the young were allowed to continue suckling, but milk removal was prevented by sealing the teat ducts with adhesive,
more milk collected in the mammary glands within 8 hr and mammary blood flow was unchanged (74 ml./min. 100 g).
4. In rats which had been separated from their young for 24 hr, milk was removed from the engorged glands by allowing the
pups to suckle again. Mammary blood flow did not rise immediately following the removal of milk but only after 4 hr of suckling,
and was associated largely with an increase in cardiac output.
5. Upon resumption of suckling mammary blood flow was the same in emptied glands, and in full glands with the teats sealed.
6. When the young were removed from 15-day lactating rats mammary blood flow after 24 hr was directly related to the volume
of milk in the glands.
7. It is concluded that the accumulation of milk in the mammary gland does not mechanically restrict the flow of blood through
the tissue and that, in the rat, mammary blood flow and milk secretion are strongly dependent on a continually applied suckling
stimulus. |
| doi_str_mv | 10.1113/jphysiol.1973.sp010300 |
| format | article |
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glands.
2. When the young were removed on the 10th day of lactation the mammary glands began to fill with milk and mammary blood flow
fell from 78 ml./min. 100 g tissue to 45 ml./min. 100 g within 8 hr and decreased further to 34 ml./min. 100 g within 8 hr
and decreased further to 34 ml./min. 100 g in the next 16 hr. These changes were associated with both a fall in cardiac output
and a fall in the proportion of the cardiac output taken by the mammary glands.
3. When the young were allowed to continue suckling, but milk removal was prevented by sealing the teat ducts with adhesive,
more milk collected in the mammary glands within 8 hr and mammary blood flow was unchanged (74 ml./min. 100 g).
4. In rats which had been separated from their young for 24 hr, milk was removed from the engorged glands by allowing the
pups to suckle again. Mammary blood flow did not rise immediately following the removal of milk but only after 4 hr of suckling,
and was associated largely with an increase in cardiac output.
5. Upon resumption of suckling mammary blood flow was the same in emptied glands, and in full glands with the teats sealed.
6. When the young were removed from 15-day lactating rats mammary blood flow after 24 hr was directly related to the volume
of milk in the glands.
7. It is concluded that the accumulation of milk in the mammary gland does not mechanically restrict the flow of blood through
the tissue and that, in the rat, mammary blood flow and milk secretion are strongly dependent on a continually applied suckling
stimulus.</description><identifier>ISSN: 0022-3751</identifier><identifier>EISSN: 1469-7793</identifier><identifier>DOI: 10.1113/jphysiol.1973.sp010300</identifier><identifier>PMID: 4759094</identifier><language>eng</language><publisher>England: The Physiological Society</publisher><subject>animal science ; Animals ; Cardiac Output ; Female ; Lactation ; livestock ; Mammary Glands, Animal - blood supply ; Milk - metabolism ; Pregnancy ; Radioisotopes ; Rats ; Regional Blood Flow ; Rubidium ; Sucking Behavior ; Time ; zoology</subject><ispartof>The Journal of physiology, 1973-08, Vol.233 (1), p.111-125</ispartof><rights>1973 The Physiological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5241-73be7423f316eda3d85cea90711e95e1760972c992a85e9d5dfb454ffc1776c53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1350542/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1350542/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4759094$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hanwell, A</creatorcontrib><creatorcontrib>Linzell, J.L</creatorcontrib><title>effects of engorgement with milk and of suckling on mammary blood flow in the rat</title><title>The Journal of physiology</title><addtitle>J Physiol</addtitle><description>1. Mammary blood flow was estimated in rats by measuring the cardiac output and the proportion of it received by the mammary
glands.
2. When the young were removed on the 10th day of lactation the mammary glands began to fill with milk and mammary blood flow
fell from 78 ml./min. 100 g tissue to 45 ml./min. 100 g within 8 hr and decreased further to 34 ml./min. 100 g within 8 hr
and decreased further to 34 ml./min. 100 g in the next 16 hr. These changes were associated with both a fall in cardiac output
and a fall in the proportion of the cardiac output taken by the mammary glands.
3. When the young were allowed to continue suckling, but milk removal was prevented by sealing the teat ducts with adhesive,
more milk collected in the mammary glands within 8 hr and mammary blood flow was unchanged (74 ml./min. 100 g).
4. In rats which had been separated from their young for 24 hr, milk was removed from the engorged glands by allowing the
pups to suckle again. Mammary blood flow did not rise immediately following the removal of milk but only after 4 hr of suckling,
and was associated largely with an increase in cardiac output.
5. Upon resumption of suckling mammary blood flow was the same in emptied glands, and in full glands with the teats sealed.
6. When the young were removed from 15-day lactating rats mammary blood flow after 24 hr was directly related to the volume
of milk in the glands.
7. It is concluded that the accumulation of milk in the mammary gland does not mechanically restrict the flow of blood through
the tissue and that, in the rat, mammary blood flow and milk secretion are strongly dependent on a continually applied suckling
stimulus.</description><subject>animal science</subject><subject>Animals</subject><subject>Cardiac Output</subject><subject>Female</subject><subject>Lactation</subject><subject>livestock</subject><subject>Mammary Glands, Animal - blood supply</subject><subject>Milk - metabolism</subject><subject>Pregnancy</subject><subject>Radioisotopes</subject><subject>Rats</subject><subject>Regional Blood Flow</subject><subject>Rubidium</subject><subject>Sucking Behavior</subject><subject>Time</subject><subject>zoology</subject><issn>0022-3751</issn><issn>1469-7793</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><recordid>eNqNkktv1DAUhS1EVaYDPwHwql1l8COOxxskWvEoqgSIdm15nOvErRMPdobR_HsSZVrBjpUln--ee-RjhN5QsqKU8nf32_aQfQwrqiRf5S2hhBPyDC1oWalCSsWfowUhjBVcCvoCneV8TwjlRKlTdFpKoYgqF-gHOAd2yDg6DH0TUwMd9APe-6HFnQ8P2PT1JOadfQi-b3DscWe6zqQD3oQYa-xC3GPf46EFnMzwEp04EzK8Op5LdPfp4-3Vl-Lm2-frqw83hRWspIXkG5Al447TCmrD67WwYBSRlIISQGVFlGRWKWbWAlQtarcpRemcpVJWVvAlej_7bnebDmo7pk4m6G3yUzYdjdf_Kr1vdRN_a8oFEePmJTo_GqT4awd50J3PFkIwPcRd1mtGJKsqOYLVDNoUc07gnpZQoqcy9GMZeipDP5YxDr7-O-LT2PH1R_1y1vc-wOE_XfXt1-_TBeOcTtgSXcwmrW_avU-g57EcrYfhoEdOUz2Tb2fSmahNk3zWdz_Z9Cc4W7NSVvwPHhm1gg</recordid><startdate>19730801</startdate><enddate>19730801</enddate><creator>Hanwell, A</creator><creator>Linzell, J.L</creator><general>The Physiological Society</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19730801</creationdate><title>effects of engorgement with milk and of suckling on mammary blood flow in the rat</title><author>Hanwell, A ; Linzell, J.L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5241-73be7423f316eda3d85cea90711e95e1760972c992a85e9d5dfb454ffc1776c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1973</creationdate><topic>animal science</topic><topic>Animals</topic><topic>Cardiac Output</topic><topic>Female</topic><topic>Lactation</topic><topic>livestock</topic><topic>Mammary Glands, Animal - blood supply</topic><topic>Milk - metabolism</topic><topic>Pregnancy</topic><topic>Radioisotopes</topic><topic>Rats</topic><topic>Regional Blood Flow</topic><topic>Rubidium</topic><topic>Sucking Behavior</topic><topic>Time</topic><topic>zoology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hanwell, A</creatorcontrib><creatorcontrib>Linzell, J.L</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hanwell, A</au><au>Linzell, J.L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>effects of engorgement with milk and of suckling on mammary blood flow in the rat</atitle><jtitle>The Journal of physiology</jtitle><addtitle>J Physiol</addtitle><date>1973-08-01</date><risdate>1973</risdate><volume>233</volume><issue>1</issue><spage>111</spage><epage>125</epage><pages>111-125</pages><issn>0022-3751</issn><eissn>1469-7793</eissn><abstract>1. Mammary blood flow was estimated in rats by measuring the cardiac output and the proportion of it received by the mammary
glands.
2. When the young were removed on the 10th day of lactation the mammary glands began to fill with milk and mammary blood flow
fell from 78 ml./min. 100 g tissue to 45 ml./min. 100 g within 8 hr and decreased further to 34 ml./min. 100 g within 8 hr
and decreased further to 34 ml./min. 100 g in the next 16 hr. These changes were associated with both a fall in cardiac output
and a fall in the proportion of the cardiac output taken by the mammary glands.
3. When the young were allowed to continue suckling, but milk removal was prevented by sealing the teat ducts with adhesive,
more milk collected in the mammary glands within 8 hr and mammary blood flow was unchanged (74 ml./min. 100 g).
4. In rats which had been separated from their young for 24 hr, milk was removed from the engorged glands by allowing the
pups to suckle again. Mammary blood flow did not rise immediately following the removal of milk but only after 4 hr of suckling,
and was associated largely with an increase in cardiac output.
5. Upon resumption of suckling mammary blood flow was the same in emptied glands, and in full glands with the teats sealed.
6. When the young were removed from 15-day lactating rats mammary blood flow after 24 hr was directly related to the volume
of milk in the glands.
7. It is concluded that the accumulation of milk in the mammary gland does not mechanically restrict the flow of blood through
the tissue and that, in the rat, mammary blood flow and milk secretion are strongly dependent on a continually applied suckling
stimulus.</abstract><cop>England</cop><pub>The Physiological Society</pub><pmid>4759094</pmid><doi>10.1113/jphysiol.1973.sp010300</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0022-3751 |
| ispartof | The Journal of physiology, 1973-08, Vol.233 (1), p.111-125 |
| issn | 0022-3751 1469-7793 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1350542 |
| source | PubMed Central |
| subjects | animal science Animals Cardiac Output Female Lactation livestock Mammary Glands, Animal - blood supply Milk - metabolism Pregnancy Radioisotopes Rats Regional Blood Flow Rubidium Sucking Behavior Time zoology |
| title | effects of engorgement with milk and of suckling on mammary blood flow in the rat |
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