Tumor and host carcass changes during total parenteral nutrition in an anorectic rat-tumor system

The independent effects of total parenteral nutrition (TPN) on tumor growth and host carcass are important in designing effective nutritional support. In this study, a TPN regimen was used to keep substrate intake at normal levels during a 10-day period of tumor-induced anorexia and cachexia in rats...

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Bibliographic Details
Published in:Annals of surgery 1984-02, Vol.199 (2), p.205-210
Main Authors: POPP, M. B, KIRKEMO, A. K, MORRISON, S. D, BRENNAN, M. F
Format: Article
Language:English
Subjects:
Animals
Anorexia - etiology
Biological and medical sciences
Blood Cell Count
Blood Chemical Analysis
Body Weight
Cachexia - etiology
Energy Intake
Growth
Male
Medical sciences
Organ Size
Parenteral Nutrition
Parenteral Nutrition, Total
Rats
Rats, Inbred F344
Sarcoma, Experimental - pathology
Sarcoma, Experimental - physiopathology
Treatment with physical agents
Treatment. General aspects
Tumors
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Summary:The independent effects of total parenteral nutrition (TPN) on tumor growth and host carcass are important in designing effective nutritional support. In this study, a TPN regimen was used to keep substrate intake at normal levels during a 10-day period of tumor-induced anorexia and cachexia in rats transplanted with a sarcoma. Tumor mass was increased in TPN-supported animals compared to orally-fed controls. Tumor composition (water, fat, nitrogen) was similar in all tumors. Host carcass mass in tumor-bearing (TB) animals was increased by TPN as compared to orally-fed TB controls, but not to the same extent as in orally-fed or TPN-supported nontumor-bearing controls. Host carcass composition determinations demonstrated significantly increased fat content but no significant change in protein or water content in TB-TPN animals compared to orally-fed TB animals. This study demonstrates increased tumor growth and increased host carcass fat stores secondary to TPN.
ISSN:0003-4932
1528-1140
DOI:10.1097/00000658-198402000-00013