Reversal of hypersplenism following orthotopic liver transplantation

The purpose of this study was to clarify the effect of orthotopic liver transplantation on hypersplenism. In a 1-year period from July 1, 1986 to June 30, 1987, 196 adult patients underwent 233 orthotopic liver transplantations. Of the 58 patients with hypersplenism who were analyzed in this study,...

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Bibliographic Details
Published in:Annals of surgery 1989-08, Vol.210 (2), p.180-183
Main Authors: YANAGA, K, TZAKIS, A. G, STARZL, T. E, SHIMADA, M, CAMPBELL, W. E, MARSH, J. W, STIEBER, A. C, MAKOWKA, L, TODO, S, GORDON, R. D, IWATSUKI, S
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Female
Humans
Hypersplenism - blood
Hypersplenism - etiology
Hypersplenism - pathology
Liver Cirrhosis - blood
Liver Cirrhosis - complications
Liver Cirrhosis - pathology
Liver Diseases - complications
Liver Diseases - surgery
Liver Transplantation
Liver, biliary tract, pancreas, portal circulation, spleen
Male
Medical sciences
Middle Aged
Platelet Count
Spleen - pathology
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the digestive system
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Summary:The purpose of this study was to clarify the effect of orthotopic liver transplantation on hypersplenism. In a 1-year period from July 1, 1986 to June 30, 1987, 196 adult patients underwent 233 orthotopic liver transplantations. Of the 58 patients with hypersplenism who were analyzed in this study, hypersplenism was more commonly associated with postnecrotic cirrhosis than other kinds of liver disease (55.3% (47/85) vs. 14.5% (11/76); p less than 0.001). Postoperative platelet counts were statistically higher than preoperative values (p less than 0.05). The latest platelet counts were more than 100,000/mm3 in 53 patients (91.4%). Of the eight patients whose preoperative and postoperative spleen volumes could be compared, all showed the reduction in the spleen size (p less than 0.02). We conclude that orthotopic liver transplantation, which is a radical surgical procedure for portal hypertension, reverses hypersplenism.
ISSN:0003-4932
1528-1140
DOI:10.1097/00000658-198908000-00007