The effects of lithogenic bile on gallbladder epithelium

Prairie dogs were fed a 1.2% cholesterol diet for up to 24 weeks to evaluate the effects of lithogenic bile on the mucosa of the gallbladder. There was a progressive increase in the lithogenic index of the gallbladder bile (1.44 +/- 0.15 at 4 weeks, p less than 0.05). Fifty-five of 70 animals develo...

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Bibliographic Details
Published in:Annals of surgery 1989-09, Vol.210 (3), p.406-15; discussion 415-6
Main Authors: Moody, F G, Haley-Russell, D, Li, Y F, Husband, K J, Weisbrodt, N W, Dewey, R B
Format: Article
Language:English
Subjects:
Absorption
Animals
Bile - analysis
Bile - physiology
Cholelithiasis - etiology
Cholesterol, Dietary - pharmacology
Electrophysiology
Gallbladder - metabolism
Gallbladder - physiology
Gallbladder - ultrastructure
Male
Microscopy, Electron, Scanning
Mucous Membrane - metabolism
Mucous Membrane - physiology
Mucous Membrane - ultrastructure
Sciuridae
Sodium - metabolism
Water - metabolism
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Summary:Prairie dogs were fed a 1.2% cholesterol diet for up to 24 weeks to evaluate the effects of lithogenic bile on the mucosa of the gallbladder. There was a progressive increase in the lithogenic index of the gallbladder bile (1.44 +/- 0.15 at 4 weeks, p less than 0.05). Fifty-five of 70 animals developed gallstones between the second and fourth week. Increasing stone burden was associated with a 27% (p less than 0.05) decrease in the electrical resistance of the epithelium and a 60% (p less than 0.05) decrease in net sodium transport when measured isotopically in an Ussing chamber (3 weeks). After 4 months, seven of ten animals developed inflammatory mucosal polyps characterized by a heavy infiltration of plasma cells into an expanded matrix. Cellular infiltration began as early as 2 weeks. These changes occurred without alterations in the ultrastructural appearance of the epithelium.
ISSN:0003-4932
1528-1140
DOI:10.1097/00000658-198909000-00016