Effects of two medicinal plants Psidium guajava L. (Myrtaceae) and Diospyros mespiliformis L. (Ebenaceae) leaf extracts on rat skeletal muscle cells in primary culture

Crude decoction, aqueous and ethanolic extracts of two medicinal plants (Psidium guajava and Diospyros mespiliformis), widely used in the central plateau of Burkina Faso to treat many diseases were evaluated for their antagonistic effects on caffeine induced calcium release from sarcoplasmic reticul...

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Bibliographic Details
Published in:Journal of Zhejiang University. B. Science 2006, Vol.7 (1), p.56-63
Main Authors: Belemtougri, R G, Constantin, B, Cognard, C, Raymond, G, Sawadogo, L
Format: Article
Language:English
Subjects:
Animals
Calcium - metabolism
Cells
Cells, Cultured
Dose-Response Relationship, Drug
Ebenaceae - chemistry
Human health and pathology
Life Sciences
Muscle Fibers, Skeletal - drug effects
Muscle Fibers, Skeletal - metabolism
Muscular system
Pharmaceutical sciences
Pharmacology
Plant & Animal Sciences
Plant Extracts - administration & dosage
Plant Leaves - chemistry
Plants, Medicinal - chemistry
Proteins
Psidium - chemistry
Rats
Rodents
Tissues and Organs
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Summary:Crude decoction, aqueous and ethanolic extracts of two medicinal plants (Psidium guajava and Diospyros mespiliformis), widely used in the central plateau of Burkina Faso to treat many diseases were evaluated for their antagonistic effects on caffeine induced calcium release from sarcoplasmic reticulum of rat skeletal muscle cells. These different extracts showed a decrease of caffeine induced calcium release in a dose dependent manner. Comparison of the results showed that Psidium guajava leaf extracts are more active than extracts of Diospyros mespiliformis and that crude decoctions show better inhibitory activity. The observed results could explain their use as antihypertensive and antidiarrhoeal agents in traditional medicine, by inhibiting intracellular calcium release.
ISSN:1673-1581
1862-1783
DOI:10.1631/jzus.2006.b0056