Acid secretion and sensitivity to gastrin in patients with duodenal ulcer: effect of eradication of Helicobacter pylori

The effect of ulcer healing with eradication of Helicobacter pylori (H pylori) on gastric function was investigated in nine patients with duodenal ulcer disease. One month after eradication there were significant reductions in both basal plasma gastrin concentration, from a median (range) of 19 (1-2...

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Bibliographic Details
Published in:Gut 1993-07, Vol.34 (7), p.888-892
Main Authors: Moss, S F, Calam, J
Format: Article
Language:English
Subjects:
Acute Disease
Adult
Aged
Bacterial diseases
Bacterial diseases of the digestive system and abdomen
Biological and medical sciences
Bismuth - therapeutic use
Drug Therapy, Combination
Duodenal Ulcer - drug therapy
Duodenal Ulcer - metabolism
Gastric Acid - metabolism
Gastrins - metabolism
Gastrins - pharmacology
Helicobacter Infections - drug therapy
Helicobacter pylori
Human bacterial diseases
Humans
Infectious diseases
Male
Medical sciences
Metronidazole - therapeutic use
Middle Aged
Organometallic Compounds - therapeutic use
Parietal Cells, Gastric - drug effects
Tetracycline - therapeutic use
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Summary:The effect of ulcer healing with eradication of Helicobacter pylori (H pylori) on gastric function was investigated in nine patients with duodenal ulcer disease. One month after eradication there were significant reductions in both basal plasma gastrin concentration, from a median (range) of 19 (1-22) to 6 (2-15) pmol/l (p < 0.05), and of basal acid secretion from 8.3 (2.4-24) to 2.6 (1.4-8.1) mM H+/h, (p < 0.01). The peak acid secretion rate was unchanged from 37 (16-59) to 37 (21-59) mM H+/h. After treatment there was no change in the parietal cell sensitivity to stepped infusions of gastrin heptadecapeptide: the median concentration of gastrin required for 50% of maximal acid secretion (EC50) was 41 (14.8-126) before and 33 (23-125) pmol/l after eradication of H pylori. The metabolic clearance rate of gastrin was also unaffected by the eradication of H pylori. Thus eradication of H pylori infection from patients with active duodenal ulcers is accompanied by falls in both basal gastrin release and basal acid secretion without a change in the parietal cell sensitivity to gastrin. Cyclical changes in H pylori infection may cause the variations in basal acid secretion that are seen in duodenal ulcer disease.
ISSN:0017-5749
1468-3288
1458-3288
DOI:10.1136/gut.34.7.888