Combined Linkage and Association Sib-Pair Analysis for Quantitative Traits

An extension to current maximum-likelihood variance-components procedures for mapping quantitative-trait loci in sib pairs that allows a simultaneous test of allelic association is proposed. The method involves modeling of the allelic means for a test of association, with simultaneous modeling of th...

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Bibliographic Details
Published in:American journal of human genetics 1999, Vol.64 (1), p.259-267
Main Authors: Fulker, D.W., Cherny, S.S., Sham, P.C., Hewitt, J.K.
Format: Article
Language:English
Subjects:
Association
Biological and medical sciences
General aspects. Genetic counseling
Genetic Linkage
Genotype
Humans
Linkage disequilibrium
Medical genetics
Medical sciences
Models, Genetic
Multipoint
Nonparametric
Nuclear Family
Quantitative Trait, Heritable
Sib pairs
Variance components
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Summary:An extension to current maximum-likelihood variance-components procedures for mapping quantitative-trait loci in sib pairs that allows a simultaneous test of allelic association is proposed. The method involves modeling of the allelic means for a test of association, with simultaneous modeling of the sib-pair covariance structure for a test of linkage. By partitioning of the mean effect of a locus into between- and within-sibship components, the method controls for spurious associations due to population stratification and admixture. The power and efficacy of the method are illustrated through simulation of various models of both real and spurious association.
ISSN:0002-9297
1537-6605
DOI:10.1086/302193