Histamine concentration of gastric mucosa in Helicobacter pylori positive and negative children

The histamine concentration was determined by enzymatic isotopic method in biopsy specimens of oxyntic mucosa from 37 children. Nineteen of the 37 had Helicobacter pylori associated gastritis (9 with duodenal ulcer). The histamine concentration in the H pylori negative group was mean (SD) 54.1 (23.1...

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Bibliographic Details
Published in:Gut 1991-05, Vol.32 (5), p.464-466
Main Authors: Queiroz, D M, Mendes, E N, Rocha, G A, Barbosa, A J, Carvalho, A S, Cunha-Melo, J R
Format: Article
Language:English
Subjects:
Adolescent
Bacterial diseases
Bacterial diseases of the digestive system and abdomen
Biological and medical sciences
Child
Child, Preschool
Duodenal Ulcer - complications
Female
Gastric Mucosa - chemistry
Gastric Mucosa - microbiology
Gastric Mucosa - pathology
Gastritis - etiology
Helicobacter Infections - complications
Helicobacter Infections - metabolism
Helicobacter Infections - pathology
Helicobacter pylori - isolation & purification
Histamine - analysis
Human bacterial diseases
Humans
Infant
Infectious diseases
Male
Medical sciences
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Summary:The histamine concentration was determined by enzymatic isotopic method in biopsy specimens of oxyntic mucosa from 37 children. Nineteen of the 37 had Helicobacter pylori associated gastritis (9 with duodenal ulcer). The histamine concentration in the H pylori negative group was mean (SD) 54.1 (23.1) micrograms/g fresh weight, and that in the H pylori positive group was 26.3 (14.2) micrograms/g (p less than 0.01). There was also a significant difference between H pylori positive patients with duodenal ulcer (19.8 (6.3) micrograms/g) and those without ulcer (31.4 (17.9) micrograms/g) (p less than 0.05). These results suggest that H pylori positive patients, especially those with duodenal ulcer, have reduced 'stored' histamine, perhaps because of increased histamine liberation.
ISSN:0017-5749
1468-3288
1458-3288
DOI:10.1136/gut.32.5.464