Osteoporosis in treated adult coeliac disease

Forty five women and 10 men with coeliac disease diagnosed in adult life, who were already on a gluten free diet, had serial bone mineral density measurements at the lumbar spine and femoral neck over 12 months. Osteoporosis, defined as a bone mineral density (BMD) < or = 2 SD below the normal pe...

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Bibliographic Details
Published in:Gut 1995-05, Vol.36 (5), p.710-714
Main Authors: McFarlane, X A, Bhalla, A K, Reeves, D E, Morgan, L M, Robertson, D A
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Bone Density
Celiac Disease - complications
Celiac Disease - diet therapy
Celiac Disease - physiopathology
Diseases of the osteoarticular system
Female
Humans
Male
Medical sciences
Middle Aged
Osteoporosis - etiology
Osteoporosis - physiopathology
Osteoporosis - prevention & control
Osteoporosis. Osteomalacia. Paget disease
Prevalence
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Summary:Forty five women and 10 men with coeliac disease diagnosed in adult life, who were already on a gluten free diet, had serial bone mineral density measurements at the lumbar spine and femoral neck over 12 months. Osteoporosis, defined as a bone mineral density (BMD) < or = 2 SD below the normal peak bone mass was found in 50% of male and 47% of female coeliac patients. Patients with a BMD < or = 2 SD below age and sex matched normal subjects, had a significantly lower body mass index (21.3 kg.m-2 compared with 25.2 kg.m-2, p < 0.02 Wilcoxon rank sum test) and lower average daily calcium intake (860 mg/day compared with 1054 mg/day, p < 0.05 Wilcoxon rank sum test) than patients with normal bone mineral density. In postmenopausal women with coeliac disease there was a strong correlation between the age at menopause and BMD at both the lumbar spine (r = 0.681, p < 0.01, Spearman's rank correlation) and femoral neck (r = 0.632, p < 0.01). No overall loss of bone was shown over the 12 months of follow up, and relative to the reference population there was a significant improvement in BMD at the lumbar spine in women (p < 0.025, paired t test) and at the femoral neck in men (p < 0.05, paired t test). There was a significant negative correlation between the annual percentage change in BMD at the lumbar spine and the duration of gluten free diet (r = -0.429, p
ISSN:0017-5749
1468-3288
1458-3288
DOI:10.1136/gut.36.5.710