Attenuated GLP-1 secretion in obesity: cause or consequence?

BACKGROUND: Hypersecretion of insulinotropic factors such as glucose dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1(7-36)amide (GLP-1) have been postulated to account for the hyperinsulinaemia of obesity. AIMS: To examine the role of GLP-1 and GIP in obese women and matched c...

Full description

Saved in:
Bibliographic Details
Published in:Gut 1996-06, Vol.38 (6), p.916-919
Main Authors: Ranganath, L R, Beety, J M, Morgan, L M, Wright, J W, Howland, R, Marks, V
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Case-Control Studies
Dietary Carbohydrates - pharmacology
Dietary Fats - pharmacology
Female
Gastric Inhibitory Polypeptide - blood
Gastric Inhibitory Polypeptide - drug effects
Glucagon
Glucagon-Like Peptide 1
Glucagon-Like Peptides
Heparin - pharmacology
Humans
Medical sciences
Metabolic diseases
Obesity
Obesity - metabolism
Peptide Fragments - blood
Peptide Fragments - drug effects
Radioimmunoassay
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:BACKGROUND: Hypersecretion of insulinotropic factors such as glucose dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1(7-36)amide (GLP-1) have been postulated to account for the hyperinsulinaemia of obesity. AIMS: To examine the role of GLP-1 and GIP in obese women and matched controls. SUBJECTS: Six lean and six obese women subjects matched for age. METHODS: The gut hormone, plasma glucose, and serum triglyceride responses were studied over 180 minutes after oral carbohydrate and fat meals. Heparin (10,000 units) was given intravenously at 120 minutes. RESULTS: There was pronounced attenuation of plasma GLP-1 secretion to oral carbohydrate in the obese compared with lean subjects but no such difference in response to oral fat load. There were no differences in the plasma GIP responses to carbohydrate or fat feeding. There was an apparent fall in plasma GLP-1 values in all subjects after administration of heparin. CONCLUSION: Postprandial GLP-1 secretion in response to oral carbohydrate is considerably attenuated in obese subjects. The cause of this attenuation of GLP-1 secretion is not known although we suggest that both this fall and the overall reduction in GLP-1 values in obese subjects may be related to an increase in plasma non-esterified fatty acids.
ISSN:0017-5749
1468-3288
1458-3288
DOI:10.1136/gut.38.6.916