Asymmetric non-precipitating antibodies in commercial hyperimmune gamma-globulin for therapeutic use

The presence of asymmetric (non-precipitating or co-precipitating) antibodies has been studied in three commercial preparations of antitetanus gamma-globulin. It was found that 27% of the specific antibodies are of asymmetric type, a value two to three times higher than that found in normal IgG. In...

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Bibliographic Details
Published in:Immunology 1992-04, Vol.75 (4), p.707-709
Main Authors: MIRANDA, S, MALAN BOREL, I, DOKMETJIAN, J, MARGNI, R. A, BINAGHI, R. A
Format: Article
Language:English
Subjects:
Animals
Antibodies, Bacterial - chemistry
Antibodies, Bacterial - immunology
Antigen-antibody reactions, antigen-antibody complexes, antibody-complement and others. Study of affinity. Antigen presentation
Biological and medical sciences
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
gamma-Globulins - chemistry
Immunization, Passive
Immunoglobulin G - chemistry
Mice
Mice, Inbred BALB C
Molecular immunology
Tetanus - prevention & control
Tetanus Toxin - immunology
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Summary:The presence of asymmetric (non-precipitating or co-precipitating) antibodies has been studied in three commercial preparations of antitetanus gamma-globulin. It was found that 27% of the specific antibodies are of asymmetric type, a value two to three times higher than that found in normal IgG. In toxicity tests in mice with tetanus toxin, the asymmetric antibodies were 2.7 times less effective than the symmetric ones. It is concluded that the protection capacity of the tetanus gamma-globulin preparations is dependent on the ratio of symmetric to asymmetric antibodies. The high content of asymmetric antibodies is probably due to the fact that immunization is performed with the antigen in a particulate form.
ISSN:0019-2805
1365-2567