Interferon-gamma as an adjuvant in immunocompromised mice

We have compared interferon-gamma (IFN-gamma) with saponin and interleukin-1 (IL-1) as adjuvants for a blood-stage malaria vaccine in mice with various immunological abnormalities. IFN-gamma was particularly effective in Biozzi low antibody responder mice, mice selectively bred to produce antibody o...

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Bibliographic Details
Published in:Immunology 1989-08, Vol.67 (4), p.520-524
Main Authors: HEATH, A. W, DEVEY, M. E, BROWN, I. N, RICHARDS, C. E, PLAYFAIR, J. H. L
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic
Animals
Antibody Affinity
Applied microbiology
Biological and medical sciences
Female
Fundamental and applied biological sciences. Psychology
Immunologic Deficiency Syndromes - immunology
Interferon-gamma - immunology
Lymphocyte Depletion
Male
Mice
Microbiology
Recombinant Proteins
T-Lymphocytes
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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Summary:We have compared interferon-gamma (IFN-gamma) with saponin and interleukin-1 (IL-1) as adjuvants for a blood-stage malaria vaccine in mice with various immunological abnormalities. IFN-gamma was particularly effective in Biozzi low antibody responder mice, mice selectively bred to produce antibody of low affinity, and mice depleted of CD4+ T cells. IFN-gamma and other cytokines may be safe adjuvants for use in human immunodeficiency states.
ISSN:0019-2805
1365-2567