Contrasuppressor cells induced by Junin virus

Intracerebral inoculation of Junin virus (JV) in all susceptible mouse models available induces a lethal meningoencephalitis compatible with a delayed-type hypersensitivity (DTH) immune response. In contrast, adult BALB/c mice prove resistant to infection and no DTH response is seen. JV inoculation...

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Bibliographic Details
Published in:Immunology 1990-04, Vol.69 (4), p.629-631
Main Authors: CAMPETELLA, O. E, GALASSI, N. V, BARRIOS, H. A
Format: Article
Language:English
Subjects:
Animals
Arenaviridae - immunology
Arenaviruses, New World - immunology
Biological and medical sciences
Delayed hypersensitivity
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Hemorrhagic Fever, American - immunology
Hypersensitivity, Delayed
Immunity, Innate
Immunobiology
Mice
Mice, Inbred BALB C
T-Lymphocytes - physiology
T-Lymphocytes, Regulatory - physiology
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Summary:Intracerebral inoculation of Junin virus (JV) in all susceptible mouse models available induces a lethal meningoencephalitis compatible with a delayed-type hypersensitivity (DTH) immune response. In contrast, adult BALB/c mice prove resistant to infection and no DTH response is seen. JV inoculation in adult BALB/c mice induces DTH suppression to unrelated antigens such as sheep red blood cells. (SRBC). This suppression is mediated by JV-induced T cells (Tsv), which are operative from 1 to 24 days post-infection (p.i.), and seems to be related to adult mouse survival. The presence of JV-induced contrasuppressor cells (CS) bearing the Thy-1+, Ly 1+2- phenotype, able to abrogate Tsv cells-mediated suppression, is described here. Thus, CS cells may be involved in the mechanism by which mice avoid over-exposure to Tsv-mediated DTH suppression. Such CS cells were found in the spleen of inoculated animals and may also be induced by transferring JV-free Tsv cells to 'naive' recipients, in which JV inoculation then induces morbidity.
ISSN:0019-2805
1365-2567