A unique role for Stat5 in recovery from acute anemia

The precise role of erythropoietin receptor-activated (EpoR-activated) Stat5 in the regulation of erythropoiesis remains unclear. In this issue of the JCI, Menon and colleagues present new experimental data that indicate a distinct role for Stat5 in the regulation of stress-induced erythropoiesis, s...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of clinical investigation 2006-03, Vol.116 (3), p.626-628
Main Author: Longmore, Gregory D
Format: Article
Language:English
Subjects:
Acute Disease
Anemia - blood
Anemia - metabolism
Animals
Biomedical research
Mice
Recovery of Function - physiology
STAT5 Transcription Factor - blood
STAT5 Transcription Factor - physiology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The precise role of erythropoietin receptor-activated (EpoR-activated) Stat5 in the regulation of erythropoiesis remains unclear. In this issue of the JCI, Menon and colleagues present new experimental data that indicate a distinct role for Stat5 in the regulation of stress-induced erythropoiesis, such as during acute anemic states (see the related article beginning on page 683). A critical function for Stat5 is to promote cell survival, possibly through transcriptional induction of the antiapoptotic protein Bcl-x. In the present experimental system, erythropoietin-Stat5 signals did not induce Bcl-x expression but did induce oncostatin-M. Moreover, oncostatin-M was found to enhance survival of erythroid progenitors. This work differentiates between steady-state (or homeostatic) erythropoiesis and stress-induced erythropoiesis at the level of EpoR signaling.
ISSN:0021-9738
1558-8238
DOI:10.1172/JCI27988