Future possibilities in the prevention of breast cancer: role of genetic variation in breast cancer prevention

Risk factors for breast cancer are related to endogenous hormones and reproductive events. As such, traditional cancer prevention strategies are not easily applicable. Tamoxifen and other selective estrogen receptor modulators (SERMs) offer a new preventive strategy for some high-risk women, but hav...

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Bibliographic Details
Published in:Breast cancer research : BCR 2000-01, Vol.2 (4), p.277-282, Article 277
Main Authors: Feigelson, H S, Henderson, B E
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Analysis
Anticarcinogenic Agents - therapeutic use
Aromatase - genetics
Aromatase - metabolism
Breast cancer
Breast Neoplasms - epidemiology
Breast Neoplasms - genetics
Breast Neoplasms - prevention & control
Cancer
Case-Control Studies
Cervical cancer
Disease susceptibility
Epidemiology
Estradiol Dehydrogenases - genetics
Estradiol Dehydrogenases - metabolism
Estrogen
Estrogen Receptor alpha
Estrogens - metabolism
Ethnic Groups - genetics
Female
Forecasting
Genetic aspects
Genetic Predisposition to Disease
Genetic Testing
Health aspects
Humans
Middle Aged
Models, Genetic
Ovary - metabolism
Polymorphism, Genetic
Prevention
Raloxifene Hydrochloride - therapeutic use
Receptors, Estrogen - genetics
Receptors, Estrogen - metabolism
Reproductive History
Review
Risk Factors
Selective Estrogen Receptor Modulators - therapeutic use
Steroid 17-alpha-Hydroxylase - genetics
Steroid 17-alpha-Hydroxylase - metabolism
Tamoxifen
Tamoxifen - therapeutic use
Women
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Description
Summary:Risk factors for breast cancer are related to endogenous hormones and reproductive events. As such, traditional cancer prevention strategies are not easily applicable. Tamoxifen and other selective estrogen receptor modulators (SERMs) offer a new preventive strategy for some high-risk women, but have not yet been shown to be efficacious for all women. New tools to identify high-risk women are needed. One such tool is the development of a multigenic model of breast cancer susceptibility that can be used to screen women in order to identify those who carry a combination of alleles that puts them at significantly increased risk.
ISSN:1465-5411
1465-542X
1465-542X
DOI:10.1186/bcr69