The effect of hepatic blood inflow occlusion on hepatic cancer treated with diode-laser thermocoagulation

Objective: To assess the effect of temporary occlusion of hepatic blood inflow on hepatic cancer treated with diode-laser induced thermocogation (LITT). Methods: The carcinoma Walker-256 was implanted in 40 SD rat livers. Twelve days later, the animals were randomly divided into 4 groups. Group A re...

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Published in:Journal of Zhejiang University. B. Science 2005-04, Vol.6 (4), p.232-235
Main Author: 洪德飞 李松英 童利民 陈斌 彭淑牖
Format: Article
Language:English
Subjects:
Animals
Biomedicine
Laser Coagulation
Liver Circulation - physiology
Liver Neoplasms - blood supply
Liver Neoplasms - surgery
Rats
Temperature
Time Factors
激光治疗
肝脏血液
血管闭塞
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Summary:Objective: To assess the effect of temporary occlusion of hepatic blood inflow on hepatic cancer treated with diode-laser induced thermocogation (LITT). Methods: The carcinoma Walker-256 was implanted in 40 SD rat livers. Twelve days later, the animals were randomly divided into 4 groups. Group A received LITT alone; group B received hepatic artery temporary occlusion during LITT; group C received portal vein temporary occlusion during LITT; group D received hepatic artery and portal vein temporary occlusion during LITT. Tumors were exposed to 810 nm diode-laser light at 0.95 watts for 10 min from a scanner tip applicator placed in the tumor. At the same time, the intrahepatic temperature distribution in rats with liver tumors was measured per 2 min during thermocoagulation. Tumor control was examined immediately 7 and 14 d after thermocoagulation. Results: There was significant difference of intrahepatic temperature distribution in rats with liver tumors among the 4 groups (P0.05). Light microscopic examination of the histologic section samples revealed three separate zones: regular hyperthermic coagulation necrosis zone, transition zone and reference zone. Compared with the samples in group A and group B, group C and group D samples had more clear margin among the three zones. Conclusion: The hepatic blood inflow occlusion, especially portal vein hepatic blood inflow occlusion, or all hepatic blood inflow occlusion considerably increased the efficacy of LITT in the treatment of liver cancer.
ISSN:1673-1581
1009-3095
1862-1783
DOI:10.1631/jzus.2005.B0232