Transforming growth factor-beta and breast cancer: Cell cycle arrest by transforming growth factor-beta and its disruption in cancer

Altered responsiveness to extracellular signals and cell cycle dysregulation are hallmarks of cancer. The cell cycle is governed by cyclin-dependent kinases (cdks) that integrate mitogenic and growth inhibitory signals. Transforming growth factor (TGF)-beta mediates G1 cell cycle arrest by inducing...

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Bibliographic Details
Published in:Breast cancer research : BCR 2000-01, Vol.2 (2), p.116-124, Article 116
Main Authors: Donovan, J, Slingerland, J
Format: Article
Language:English
Subjects:
Bone morphogenetic proteins
Breast cancer
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Cell cycle
Cell Cycle - physiology
Cyclins - metabolism
Development and progression
Female
Genes, myc - physiology
Genes, ras - physiology
Humans
Phosphorylation
Phosphotransferases
Review
Transforming Growth Factor beta - metabolism
Transforming growth factors
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Summary:Altered responsiveness to extracellular signals and cell cycle dysregulation are hallmarks of cancer. The cell cycle is governed by cyclin-dependent kinases (cdks) that integrate mitogenic and growth inhibitory signals. Transforming growth factor (TGF)-beta mediates G1 cell cycle arrest by inducing or activating cdk inhibitors, and by inhibiting factors required for cdk activation. Mechanisms that lead to cell cycle arrest by TGF-beta are reviewed. Loss of growth inhibition by TGF-beta occurs early in breast cell transformation, and may contribute to breast cancer progression. Dysregulation of cell cycle effectors at many different levels may contribute to loss of G1 arrest by TGF-beta. Elucidation of these pathways in breast cancer may ultimately lead to novel and more effective treatments for this disease.
ISSN:1465-5411
1465-542X
1465-542X
DOI:10.1186/bcr43