The effect of procaine on neuromuscular transmission

1. The mechanism of procaine action on post-synaptic receptors for acetylcholine was studied by recording the end-plate current at membrane potentials ranging from about +30 to about -140 mV. 2. It has been found that at resting membrane potential of about -60 to -80 mV the end-plate current has a f...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of physiology 1970-08, Vol.209 (3), p.689-699
Main Author: Kordas, M
Format: Article
Language:English
Subjects:
Acetylcholine
Animals
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:1. The mechanism of procaine action on post-synaptic receptors for acetylcholine was studied by recording the end-plate current at membrane potentials ranging from about +30 to about -140 mV. 2. It has been found that at resting membrane potential of about -60 to -80 mV the end-plate current has a fast initial and a slow late component. During hyperpolarization of the muscle fibre the amplitude of the slow component is depressed and its half-time lengthened. When the membrane potential is inverted the difference in the time course of both components is much less pronounced or absent. 3. It is suggested that procaine modifies the receptor response induced by acetylcholine, and that this modification is dependent on membrane potential.
ISSN:0022-3751
1469-7793
DOI:10.1113/jphysiol.1970.sp009186