Studies in pharmacokinetics and tolerance of substances temporarily retained in the liver by microsphere embolization

Earlier investigation has shown that a temporary arrest of arterial blood flow can be achieved by embolization with degradable microspheres. This study was made to investigate the change in pharmacokinetics, and drug tolerance which takes place when a substance is retained in the liver by a microsph...

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Bibliographic Details
Published in:Annals of surgery 1978-01, Vol.187 (1), p.95-99
Main Authors: Lindell, B, Aronsen, K F, Nosslin, B, Rothman, U
Format: Article
Language:English
Subjects:
Animals
Drug Tolerance
Embolization, Therapeutic
Fluorouracil - administration & dosage
Fluorouracil - metabolism
Insulin - administration & dosage
Insulin - metabolism
Kinetics
Liver - blood supply
Male
Microspheres
Rats
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Summary:Earlier investigation has shown that a temporary arrest of arterial blood flow can be achieved by embolization with degradable microspheres. This study was made to investigate the change in pharmacokinetics, and drug tolerance which takes place when a substance is retained in the liver by a microsphere embolization. 14C-labelled inulin and 5-fluorouracil were studied. The administration of these substances with microspheres led to a delay in their systemic distribution. Furthermore there was an increased tolerance to 5-fluoro-uracil, probably due to a prolonged first pass effect when the substance was temporarily retained in the liver by a microsphere embolization.
ISSN:0003-4932
1528-1140
DOI:10.1097/00000658-197801000-00018