The preclotting of porous arterial prostheses

A four-step preclotting method is presented for use with porous filamentous Dacron prostheses in the fully-heparinized patient. The method employs controlled fibrin formation within graft interstices, heparin neutralization of all thrombin remaining in the graft wall, and delay of systemic heparin n...

Full description

Saved in:
Bibliographic Details
Published in:Annals of surgery 1978-11, Vol.188 (5), p.611-622
Main Authors: Yates, S G, Barros D'Sa, A A, Berger, K, Fernandez, L G, Wood, S J, Rittenhouse, E A, Davis, C C, Mansfield, P B, Sauvage, L R
Format: Article
Language:English
Subjects:
Animals
Blood
Blood Coagulation
Blood Vessel Prosthesis - methods
Carotid Arteries - surgery
Dogs
Heparin - therapeutic use
Humans
Polyethylene Terephthalates
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A four-step preclotting method is presented for use with porous filamentous Dacron prostheses in the fully-heparinized patient. The method employs controlled fibrin formation within graft interstices, heparin neutralization of all thrombin remaining in the graft wall, and delay of systemic heparin neutralization until 15--20 minutes after clamp release. The resulting flow surface is impervious, smooth and hypothrombogenic. Experimental data are presented which support the rationale of this four-step preclotting method. Four years of clinical experience with the method are summarized, involving 300 prosthesis limbs used in aortic bifurcation, aortofemoral, femorofemoral, axillary-femoral and femoropopliteal positions in 192 patients. A clinical perspective of preclotting techniques is presented in which the proper use of this new method is suggested.
ISSN:0003-4932
1528-1140
DOI:10.1097/00000658-197811000-00005