Intimal thickening and hyperlipidemia in experimental primate vascular autografts

Intimal thickening is a significant cause of late failure of aorto-coronary vein grafts. The microscopic appearance of this thickening has some similarities to the microscopic appearance of arterial atherosclerosis, and it has been suggested that hyperlipidemia may play a role in its pathogenesis. T...

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Bibliographic Details
Published in:Annals of surgery 1979-01, Vol.189 (1), p.62-67
Main Authors: McCann, R L, Larson, R M, Mitchener, 3rd, J S, Fuchs, J C, Hagen, P O
Format: Article
Language:English
Subjects:
Animals
Arteries - metabolism
Arteries - transplantation
Arteries - ultrastructure
Dietary Fats
Haplorhini
Hyperlipidemias
Iliac Artery - surgery
Jugular Veins - surgery
Lipid Metabolism
Macaca mulatta
Transplantation, Autologous
Veins - metabolism
Veins - transplantation
Veins - ultrastructure
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Summary:Intimal thickening is a significant cause of late failure of aorto-coronary vein grafts. The microscopic appearance of this thickening has some similarities to the microscopic appearance of arterial atherosclerosis, and it has been suggested that hyperlipidemia may play a role in its pathogenesis. This study examines the morphology and lipid composition of autologous vein and artery grafts in normal and hyperlipidemic rhesus monkeys. Grafts were examined six months after insertion by light and electron microscopy and tissue lipids were determined quantitatively. Intimal thickening occurred in all grafts. Specific morphological and lipid compositional features of the grafts were influenced by the type of tissue used for grafting and the presence or absence of hyperlipidemia. However, the degree of intimal thickening per se could not be related to either of these two factors. It is concluded that surgical transplantation in this model provides the most powerful stimulus for intimal thickening and any additional effect on this process by hyperlipidemia is small.
ISSN:0003-4932
1528-1140
DOI:10.1097/00000658-197901000-00013