The role of cavitation in acoustically activated drug delivery

Pluronic P105 micelles are potential candidates as chemotherapy drug delivery vehicles using ultrasonic stimulation as a release trigger. Acoustic power has been previously shown to release two anthracycline agents from these polymeric carriers. In this study, an ultrasonic exposure chamber with flu...

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Bibliographic Details
Published in:Journal of controlled release 2005-10, Vol.107 (2), p.253-261
Main Authors: Husseini, Ghaleb A., Diaz de la Rosa, Mario A., Richardson, Eric S., Christensen, Douglas A., Pitt, William G.
Format: Article
Language:English
Subjects:
Acoustic spectroscopy
Antibiotics, Antineoplastic - administration & dosage
Antibiotics, Antineoplastic - chemistry
Biological and medical sciences
Cavitation events
Doxorubicin
Doxorubicin - administration & dosage
Doxorubicin - chemistry
Drug Carriers
Drug Delivery Systems
Fluorescence measurements
General pharmacology
Medical sciences
Micelles
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Pluronic micelles
Poloxamer
Spectrometry, Fluorescence
Ultrasonics
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Summary:Pluronic P105 micelles are potential candidates as chemotherapy drug delivery vehicles using ultrasonic stimulation as a release trigger. Acoustic power has been previously shown to release two anthracycline agents from these polymeric carriers. In this study, an ultrasonic exposure chamber with fluorescence detection was used to examine the mechanism of doxorubicin release from P105 micelles. Acoustic spectra were collected and analyzed, at the same spatial position as fluorescence data, to probe the role of cavitation in drug release. Our study showed a strong correlation between percent drug release and subharmonic acoustic emissions, and we attribute the drug release to collapse cavitation that perturbs the structure of the micelle and releases drug.
ISSN:0168-3659
1873-4995
DOI:10.1016/j.jconrel.2005.06.015