Challenge with Bovine viral diarrhea virus by exposure to persistently infected calves: protection by vaccination and negative results of antigen testing in nonvaccinated acutely infected calves

Calves persistently infected (PI) with Bovine viral diarrhea virus (BVDV) represent an important source of infection for susceptible cattle. We evaluated vaccine efficacy using calves PI with noncytopathic BVDV2a for the challenge and compared tests to detect BVDV in acutely or transiently infected...

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Bibliographic Details
Published in:Canadian journal of veterinary research 2006-04, Vol.70 (2), p.121-127
Main Authors: Fulton, Robert W, Johnson, Bill J, Briggs, Robert E, Ridpath, Julia F, Saliki, Jeremiah T, Confer, Anthony W, Burge, Lurinda J, Step, Douglas L, Walker, Derek A, Payton, Mark E
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Antibodies, Viral
Antibodies, Viral - blood
Antibody Formation
Antibody Formation - physiology
Antigens, Viral
Antigens, Viral - immunology
blood
Bovine viral diarrhea virus 1
Bovine viral diarrhea virus 2
Bovine Virus Diarrhea-Mucosal Disease
Bovine Virus Diarrhea-Mucosal Disease - blood
Bovine Virus Diarrhea-Mucosal Disease - prevention & control
calves
Cattle
classification
Diarrhea Virus 1, Bovine Viral
Diarrhea Virus 1, Bovine Viral - immunology
Diarrhea Virus 2, Bovine Viral
Diarrhea Virus 2, Bovine Viral - immunology
Diarrhea Viruses, Bovine Viral
Diarrhea Viruses, Bovine Viral - classification
Diarrhea Viruses, Bovine Viral - immunology
Diarrhea Viruses, Bovine Viral - isolation & purification
disease detection
Disease Susceptibility
Disease Susceptibility - veterinary
enzyme-linked immunosorbent assay
Enzyme-Linked Immunosorbent Assay - veterinary
immunohistochemistry
Immunohistochemistry - veterinary
immunology
isolation & purification
live vaccines
Nose
Nose - virology
pharmacology
physiology
prevention & control
vaccination
Vaccines, Attenuated
Vaccines, Attenuated - immunology
Vaccines, Attenuated - pharmacology
Vaccines, Inactivated
Vaccines, Inactivated - immunology
Vaccines, Inactivated - pharmacology
veterinary
Viral Vaccines
Viral Vaccines - immunology
Viral Vaccines - pharmacology
Viremia
Viremia - veterinary
virology
Virus Shedding
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Summary:Calves persistently infected (PI) with Bovine viral diarrhea virus (BVDV) represent an important source of infection for susceptible cattle. We evaluated vaccine efficacy using calves PI with noncytopathic BVDV2a for the challenge and compared tests to detect BVDV in acutely or transiently infected calves versus PI calves. Vaccination with 2 doses of modified live virus vaccine containing BVDV1a and BVDV2a protected the calves exposed to the PI calves: neither viremia nor nasal shedding occurred. An immunohistochemistry test on formalin-fixed ear notches and an antigen-capture enzyme-linked immunosorbent assay on fresh notches in phosphate-buffered saline did not detect BVDV antigen in any of the acutely or transiently infected calves, whereas both tests had positive results in all the PI calves.
ISSN:0830-9000