Function and structure of the mucosa of continent ileostomy reservoirs in dogs

Continent ileostomy reservoirs were constructed in dogs. Nine to 29 days after formation of the pouches, they were excised together with a loop of adjacent ileum for biochemical and morphological assessment. The villous and epithelial cell heights were reduced, whereas villous width and mitotic inde...

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Bibliographic Details
Published in:Gut 1975-02, Vol.16 (2), p.132-136
Main Authors: Philipson, Kock, N G, Robinson, J W, Menge, H, Mirkovitch, V
Format: Article
Language:English
Subjects:
Acid Phosphatase - metabolism
Animals
Biological Transport, Active
Dogs
Epithelial Cells
Epithelium - metabolism
Female
Ileostomy - methods
Ileum - anatomy & histology
Ileum - metabolism
Intestinal Absorption
Intestinal Mucosa - anatomy & histology
Intestinal Mucosa - metabolism
Inulin - metabolism
Male
Methylglucosides - metabolism
Mitosis
Oxygen Consumption
Phenylalanine - metabolism
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Description
Summary:Continent ileostomy reservoirs were constructed in dogs. Nine to 29 days after formation of the pouches, they were excised together with a loop of adjacent ileum for biochemical and morphological assessment. The villous and epithelial cell heights were reduced, whereas villous width and mitotic index were increased. The mucosa of the pouch was able to absorb phenylalanine and Beta-methyl-glucoside against a concentration gradient, although this absorptive capaciti was lower than that of normal ileum. Similar considerations applied to oxygen consumption. The results indicate that the mucosa of the pouch undergoes transformation, but the intergrity of the epithelial layer is maintained.
ISSN:0017-5749
1468-3288
1458-3288
DOI:10.1136/gut.16.2.132