Double-blind trial of cholestyramine in post-vagotomy diarrhoea

The effect of cholestyramine in post-vagotomy diarrhoea has been assessed under double-blind conditions. Cholestyramine produced a significant improvement in frequency, urgency, and consistency of stool as well as episodic diarrhoea. Faecal bile acid excretion was significantly higher in the post-va...

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Bibliographic Details
Published in:Gut 1977-07, Vol.18 (7), p.531-535
Main Authors: Duncombe, V M, Bolin, T D, Davis, A E
Format: Article
Language:English
Subjects:
Bile Acids and Salts - metabolism
Cholestyramine Resin - therapeutic use
Clinical Trials as Topic
Diarrhea - drug therapy
Diarrhea - etiology
Feces - analysis
Humans
Vagotomy - adverse effects
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Summary:The effect of cholestyramine in post-vagotomy diarrhoea has been assessed under double-blind conditions. Cholestyramine produced a significant improvement in frequency, urgency, and consistency of stool as well as episodic diarrhoea. Faecal bile acid excretion was significantly higher in the post-vagotomy group when compared with normal controls. These findings confirm the effectiveness of cholestyramine and support the concept of a bile acid mediated aetiology in post-vagotomy diarrhoea.
ISSN:0017-5749
1468-3288
1458-3288
DOI:10.1136/gut.18.7.531