Disappearance of gastrin and pentagastrin in the portal circulation

Experiments on dogs and rats showed that synthetic human gastrin I was inactivated in the small bowel but not in the liver, whereas pentagastrin was rapidly inactivated by the liver. Similar results were obtained with tissue homogenates. The significance of these results is discussed in relation to...

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Bibliographic Details
Published in:Gut 1971-05, Vol.12 (5), p.372-376
Main Authors: Temperley, John M., Stagg, Brian H., Wyllie, John H.
Format: Article
Language:English
Subjects:
Animals
Dogs
Gastric Juice - metabolism
Gastrins - metabolism
Injections, Intravenous
Intestine, Small - metabolism
Intestine, Small - surgery
Jugular Veins
Liver - metabolism
Liver Circulation
Peptic Ulcer - etiology
Peptides - metabolism
Portal Vein
Rats
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Summary:Experiments on dogs and rats showed that synthetic human gastrin I was inactivated in the small bowel but not in the liver, whereas pentagastrin was rapidly inactivated by the liver. Similar results were obtained with tissue homogenates. The significance of these results is discussed in relation to the probably increased incidence of peptic ulceration following extensive small-bowel resection in man.
ISSN:0017-5749
1468-3288
1458-3288
DOI:10.1136/gut.12.5.372