Somatostatin therapy of acute experimental pancreatitis

Because somatostatin (SRIF) reduces exocrine pancreatic secretion, its effect on acute pancreatitis was investigated in rats. Linear SRIF reduced serum amylase and lipase but had no effect on pancreatic necrosis, oedema, leucocyte infiltration, and enzyme content. The mortality rate was not reduced....

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Bibliographic Details
Published in:Gut 1977-09, Vol.18 (9), p.713-716
Main Authors: Lankisch, P G, Koop, H, Winckler, K, Fölsch, U R, Creutzfeldt, W
Format: Article
Language:English
Subjects:
Acute Disease
Animals
Male
Pancreatitis - chemically induced
Pancreatitis - drug therapy
Pancreatitis - enzymology
Rats
Somatostatin - therapeutic use
Taurocholic Acid
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Summary:Because somatostatin (SRIF) reduces exocrine pancreatic secretion, its effect on acute pancreatitis was investigated in rats. Linear SRIF reduced serum amylase and lipase but had no effect on pancreatic necrosis, oedema, leucocyte infiltration, and enzyme content. The mortality rate was not reduced. These results do not recommend the use of SRIF in the treatment of acute pancreatitis.
ISSN:0017-5749
1468-3288
1458-3288
DOI:10.1136/gut.18.9.713