Inhibitory effect of cimetidine on gastric acid secretion vagally activated by physiological means in duodenal ulcer patients

Vagal activation of gastric acid secretion by modified sham feeding in six patients with duodenal ulcer produced a peak acid response amounting to 52% of the peak acid output after pentagastrin stimulation (PAOpg). Cholinergic reflex stimulation of gastric acid secretion by fundic distension in anot...

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Bibliographic Details
Published in:Gut 1978-01, Vol.19 (1), p.27-31
Main Authors: Schöön, I M, Olbe, L
Format: Article
Language:English
Subjects:
Adult
Cimetidine - pharmacology
Duodenal Ulcer - physiopathology
Gastric Juice - metabolism
Guanidines - pharmacology
Humans
Male
Middle Aged
Secretory Rate - drug effects
Stomach - physiology
Vagus Nerve - physiology
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Summary:Vagal activation of gastric acid secretion by modified sham feeding in six patients with duodenal ulcer produced a peak acid response amounting to 52% of the peak acid output after pentagastrin stimulation (PAOpg). Cholinergic reflex stimulation of gastric acid secretion by fundic distension in another six patients with duodenal ulcer produced a peak acid response of 45% of PAOpg. Intravenous infusion of cimetidine in a dose of 100 mg/h markedly inhibited the acid sham feeding response by 90-100% and almost abolished the acid response to fundic distension. The results suggest that gastric acid secretion evoked by physiological vagal activation in man is profoundly inhibited by H2-receptor blocking agents.
ISSN:0017-5749
1468-3288
1458-3288
DOI:10.1136/gut.19.1.27